Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 6/20 | 0.57 |
| ▸ | KIT | P10721 | 5/20 | 0.57 |
| ▸ | FLT3 | P36888 | 5/20 | 0.57 |
| ▸ | NCF1 | P14598 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 2/20 | 0.37 |
| ▸ | ABL1 | P00519 | 2/20 | 0.37 |
| ▸ | BCR | P11274 | 2/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.35 |
| ▸ | CHUK | O15111 | 1/20 | 0.35 |
| ▸ | INSR | P06213 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28760142 | 0.90 | KDR (0.58) | KDRKITFLT3JAK2ABL1 | |
| SCHEMBL27657311 | 0.88 | KDR (0.56) | KDRKITFLT3ABL1BCR | |
| SCHEMBL27657354 | 0.86 | KDR (0.51) | KDRKITFLT3NCF1IKBKE | |
| SCHEMBL27657288 | 0.83 | KDR (0.52) | KDRKITFLT3JAK2ABL1 | |
| SCHEMBL27657308 | 0.82 | KDR (0.43) | KDRKITFLT3JAK2ABL1 | |
| SCHEMBL27636389 | 0.81 | KDR (0.49) | KDRKITFLT3JAK2ABL1 | |
| SCHEMBL27657333 | 0.81 | KDR (0.54) | KDRKITFLT3JAK2ABL1 | |
| SCHEMBL27636462 | 0.79 | KDR (0.60) | KDRKITFLT3JAK2ABL1 | |
| SCHEMBL28760587 | 0.79 | KDR (0.44) | KDRKITFLT3NCF1JAK2 | |
| SCHEMBL13504144 | 0.79 | KDR (0.61) | KDRKITFLT3CHUKINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1826324-B | indazole, Benzisoxazole and benzisothiazole kinase inhibitors | ABBOTT LABORATORIES (US) | 2011-12-07 | — | — | CN | claimed |
| CN-1826324-A | Indazole, benzisoxazole and benzisothiazole kinase inhibitors | ABBOTT LAB (US) | 2006-08-30 | — | — | CN | claimed |
| CN-101827584-A | Solid dispersion product of N-aryl ureido drugs | ABBOTT GMBH & CO KG | 2010-09-08 | — | — | CN | disclosed |