Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 13/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 13/20 | 0.45 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
| ▸ | EIF4E | P06730 | 1/20 | 0.35 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.34 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 2/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27638483 | 0.89 | ESR1 (0.45) | ESR1ESR2ALOX5APFEN1HSD17B1 | |
| SCHEMBL3936448 | 0.86 | ESR1 (0.50) | ESR1ESR2AR | |
| SCHEMBL27638486 | 0.83 | ESR1 (0.63) | ESR1ESR2ALOX5APFEN1HSD17B1 | |
| SCHEMBL27659339 | 0.82 | ESR1 (0.50) | ESR1ESR2ALOX5APFEN1HSD17B1 | |
| SCHEMBL27659356 | 0.82 | ESR1 (0.53) | ESR1ESR2ALOX5APFEN1HSD17B1 | |
| SCHEMBL27659342 | 0.80 | ESR1 (0.54) | ESR1ESR2ALOX5APFEN1HSD17B1 | |
| SCHEMBL3929098 | 0.77 | ESR1 (0.55) | ESR1ESR2AR | |
| SCHEMBL27638481 | 0.76 | ESR1 (0.50) | ESR1ESR2ALOX5APFEN1HSD17B1 | |
| SCHEMBL27638488 | 0.73 | ESR1 (0.67) | ESR1ESR2ALOX5APFEN1HSD17B1 | |
| SCHEMBL27638498 | 0.73 | ESR2 (0.71) | ESR1ESR2ALOX5APFEN1HSD17B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1823046-A | Phenyl quinolines and their use as estrogen receptor modulators | WYETH CORP (US) | 2006-08-23 | — | — | CN | claimed |
| CN-1823046-A | Phenyl quinolines and their use as estrogen receptor modulators | WYETH CORP (US) | 2006-08-23 | — | — | CN | disclosed |