Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 4/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | SCD | O00767 | 1/20 | 0.48 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.47 |
| ▸ | ESR1 | P03372 | 1/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.47 |
| ▸ | PDE5A | O76074 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27660573 | 0.90 | MMP13 (0.64) | MMP13HDAC6HDAC1HDAC3HDAC4 | |
| SCHEMBL2313385 | 0.82 | SCD (0.64) | MMP13HDAC6HDAC1HDAC3HDAC4 | |
| SCHEMBL27660577 | 0.80 | MMP13 (0.63) | MMP13HDAC6HDAC1HDAC3HDAC4 | |
| SCHEMBL27680630 | 0.77 | MMP13 (0.52) | MMP13HDAC6HDAC1HDAC3HDAC4 | |
| SCHEMBL2314932 | 0.74 | SCD (0.66) | MMP13HDAC6SMN1; SMN2SCDSLC2A1 | |
| SCHEMBL27680615 | 0.74 | MMP13 (0.56) | MMP13HDAC6HDAC1HDAC3HDAC4 | |
| SCHEMBL2315906 | 0.73 | HDAC6 (0.59) | MMP13HDAC6HDAC1HDAC3HDAC4 | |
| SCHEMBL2619417 | 0.73 | HDAC6 (0.64) | MMP13HDAC6HDAC1HDAC3HDAC4 | |
| SCHEMBL4969416 | 0.73 | GRK2 (0.65) | MMP13SCD | |
| SCHEMBL5696952 | 0.72 | MMP13 (1.00) | MMP13SCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103012376-A | Amide derivatives | ASTRAZENECA AB | 2013-04-03 | — | — | CN | disclosed |
| CN-1898216-A | Amide derivatives | ASTRAZENECA AB (SE) | 2007-01-17 | — | — | CN | disclosed |