Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Histidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CTSC | P53634 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Histidine SCHEMBL27660744 | 0.94 | CYP3A4 (0.30) | SLC7A5CYP3A4CTSCCYP1A2 | |
| Histidine SCHEMBL1543511 | 0.94 | CYP3A4 (0.30) | SLC7A5CYP3A4CTSCCYP1A2 | |
| Histidine SCHEMBL16444321 | 0.93 | CYP3A4 (0.32) | SLC7A5CYP3A4CTSCCYP1A2 | |
| Histidine SCHEMBL2586200 | 0.93 | SLC7A5 (0.35) | SLC7A5CYP3A4CTSCCYP1A2 | |
| Histidine SCHEMBL2586203 | 0.93 | SLC7A5 (0.35) | SLC7A5CYP3A4CTSCCYP1A2 | |
| Histidine SCHEMBL27902238 | 0.93 | SLC7A5 (0.35) | SLC7A5CYP3A4CTSCCYP1A2 | |
| D-Histidine SCHEMBL11606906 | 0.93 | SLC7A5 (0.35) | SLC7A5CYP3A4CTSCCYP1A2 | |
| Histidine SCHEMBL19809592 | 0.90 | — | — | |
| Histidine SCHEMBL17685559 | 0.90 | GSR (0.33) | — | |
| Histidine SCHEMBL17165037 | 0.89 | REN (0.31) | CTSC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1889974-A | Oligopeptides as coating material for medical products | HEMOTEQ GMBH (DE) | 2007-01-03 | — | — | CN | claimed |
| CN-1889974-B | Oligopeptides as coating material for medical products | HEMOTEQ GMBH | 2012-08-29 | — | — | CN | disclosed |
| CN-1889974-A | Oligopeptides as coating material for medical products | HEMOTEQ GMBH (DE) | 2007-01-03 | — | — | CN | disclosed |