Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 11/20 | 0.70 |
| ▸ | ADORA2A | P29274 | 11/20 | 0.70 |
| ▸ | PDE4B | Q07343 | 11/20 | 0.70 |
| ▸ | PDE4C | Q08493 | 11/20 | 0.70 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.70 |
| ▸ | ADORA2B | P29275 | 10/20 | 0.64 |
| ▸ | CFTR | P13569 | 1/20 | 0.56 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | CHIT1 | Q13231 | 1/20 | 0.53 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7455363 | 0.86 | ADORA2A (0.72) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL7605748 | 0.85 | ADORA2B (0.63) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL21381258 | 0.84 | PDE4A (0.92) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| Iodide SCHEMBL28973314 | 0.83 | PDE4A (0.89) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL7458212 | 0.83 | PDE4A (0.89) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL7109948 | 0.83 | PDE4A (1.00) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL8656750 | 0.82 | PDE4A (0.87) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL7603843 | 0.81 | ADORA2B (0.54) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL7608745 | 0.80 | ADORA2B (0.71) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL7460178 | 0.80 | PDE4A (1.00) | PDE4AADORA2APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1878529-A | Combined cosmetic or therapeutic preparation | ROVI GMBH & CO KOSMETISCHE ROH (DE) | 2006-12-13 | — | — | CN | claimed |
| CN-101511364-B | Combination treatment for diabetes mellitus | NYCOMED GMBH | 2012-08-15 | — | — | CN | disclosed |
| CN-102600144-A | Roflumilast for the treatment of diabetes mellitus | NYCOMED GMBH | 2012-07-25 | — | — | CN | disclosed |
| CN-101137368-B | Roflumilast for the treatment of diabetes | NYCOMED GMBH | 2012-05-16 | — | — | CN | disclosed |
| CN-101874023-A | Alkylthio pyrimidines as CRTH2 antagonists | ACTIMIS PHARMACEUTICALS INC | 2010-10-27 | — | — | CN | disclosed |
| CN-101511364-A | Combination treatment for diabetes mellitus | NYCOMED GMBH (DE) | 2009-08-19 | — | — | CN | disclosed |
| CN-101137368-A | Roflumilast for the treatment of diabetes | NYCOMED GMBH (DE) | 2008-03-05 | — | — | CN | disclosed |
| CN-1878529-A | Combined cosmetic or therapeutic preparation | ROVI GMBH & CO KOSMETISCHE ROH (DE) | 2006-12-13 | — | — | CN | disclosed |