Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TRPC3 | Q13507 | 2/20 | 0.36 |
| ▸ | TRPC6 | Q9Y210 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5032645 | 0.90 | CYP3A4 (0.40) | KDM4EHTR2CRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL5032533 | 0.88 | HTR2C (0.42) | KDM4EHTR2CALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL5034664 | 0.87 | KMT2A (0.47) | KDM4EHTR2CALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL27664672 | 0.87 | HTR2C (0.56) | KDM4EHTR2CALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL27643396 | 0.85 | KMT2A (0.48) | HTR2CALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL5034842 | 0.85 | HTR2C (0.46) | KDM4EHTR2CALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL5034980 | 0.84 | KDM4E (0.47) | KDM4EALDH1A1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL5034975 | 0.83 | KDM4E (0.44) | KDM4EALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL5032604 | 0.80 | TRPC3 (0.42) | KDM4EHTR2CALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL5032552 | 0.80 | NPC1 (0.45) | HTR2CALDH1A1RAB9ASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100509808-C | Novel thiazole derivates | HOFFMANN LA ROCHE (CH) | 2009-07-08 | — | — | CN | claimed |
| CN-1890236-A | Novel thiazole derivates | HOFFMANN LA ROCHE (CH) | 2007-01-03 | — | — | CN | claimed |
| CN-100509808-C | Novel thiazole derivates | HOFFMANN LA ROCHE (CH) | 2009-07-08 | — | — | CN | disclosed |
| CN-1890236-A | Novel thiazole derivates | HOFFMANN LA ROCHE (CH) | 2007-01-03 | — | — | CN | disclosed |