Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 7/20 | 0.56 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | PHGDH | O43175 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 2/20 | 0.40 |
| ▸ | CNR2 | P34972 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5032522 | 0.90 | HTR2C (0.48) | HTR2CNPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL5032533 | 0.89 | HTR2C (0.42) | HTR2CNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL27643396 | 0.89 | KMT2A (0.48) | HTR2CNPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL5034664 | 0.89 | KMT2A (0.47) | HTR2CNPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL27664665 | 0.87 | KDM4E (0.40) | HTR2CNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL27643378 | 0.86 | HTR2C (0.49) | HTR2CNPC1RAB9AHPGDKMT2A | |
| SCHEMBL5034842 | 0.84 | HTR2C (0.46) | HTR2CNPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL5034878 | 0.81 | KMT2A (0.48) | RAB9ASMN1; SMN2MAPK1ALDH1A1ALOX15 | |
| SCHEMBL5034980 | 0.81 | KDM4E (0.47) | RAB9ASMN1; SMN2TP53KDM4EHPGD | |
| SCHEMBL5032552 | 0.81 | NPC1 (0.45) | HTR2CNPC1RAB9ASMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100509808-C | Novel thiazole derivates | HOFFMANN LA ROCHE (CH) | 2009-07-08 | — | — | CN | claimed |
| CN-1890236-A | Novel thiazole derivates | HOFFMANN LA ROCHE (CH) | 2007-01-03 | — | — | CN | claimed |
| CN-100509808-C | Novel thiazole derivates | HOFFMANN LA ROCHE (CH) | 2009-07-08 | — | — | CN | disclosed |
| CN-1890236-A | Novel thiazole derivates | HOFFMANN LA ROCHE (CH) | 2007-01-03 | — | — | CN | disclosed |