Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5032530 | 0.91 | HTR2C (0.43) | HTR2CHPGDNPSR1NPC1MAPT | |
| SCHEMBL27664664 | 0.91 | NPC1 (0.37) | HTR2CNPC1MAPTRAB9AKMT2A | |
| SCHEMBL27664739 | 0.87 | HTR2C (0.52) | HTR2CNPC1MAPTCNR1CNR2 | |
| SCHEMBL27664668 | 0.87 | POLB (0.43) | NPC1MAPTRAB9AKMT2ATSHR | |
| SCHEMBL5032654 | 0.86 | HTR2C (0.43) | HTR2CHPGDNPSR1NPC1MAPT | |
| SCHEMBL28761339 | 0.84 | HPGD (0.46) | HTR2CHPGDNPSR1NPC1MAPT | |
| SCHEMBL27643378 | 0.84 | HTR2C (0.49) | HTR2CHPGDNPSR1NPC1MAPT | |
| SCHEMBL5035881 | 0.83 | KMT2A (0.39) | HPGDNPC1MAPTCNR1CNR2 | |
| SCHEMBL5032532 | 0.82 | NPC1 (0.37) | NPC1MAPTRAB9AKMT2ATSHR | |
| SCHEMBL5035027 | 0.80 | HTR2C (0.48) | HTR2CHPGDNPC1MAPTCNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100509808-C | Novel thiazole derivates | HOFFMANN LA ROCHE (CH) | 2009-07-08 | — | — | CN | claimed |
| CN-1890236-A | Novel thiazole derivates | HOFFMANN LA ROCHE (CH) | 2007-01-03 | — | — | CN | claimed |
| CN-100509808-C | Novel thiazole derivates | HOFFMANN LA ROCHE (CH) | 2009-07-08 | — | — | CN | disclosed |
| CN-1890236-A | Novel thiazole derivates | HOFFMANN LA ROCHE (CH) | 2007-01-03 | — | — | CN | disclosed |