Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | SPTLC2 | O15270 | 5/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27664670 | 0.91 | HTR2C (0.47) | NPC1RAB9AHTR2CTSHRMAPT | |
| SCHEMBL5032532 | 0.91 | NPC1 (0.37) | NPC1RAB9ALMNATSHRMAPT | |
| SCHEMBL27664668 | 0.86 | POLB (0.43) | NPC1RAB9ALMNATSHRSPTLC2 | |
| SCHEMBL27664673 | 0.84 | NPC1 (0.41) | NPC1RAB9ACES2CES1HTR2C | |
| SCHEMBL5035881 | 0.84 | KMT2A (0.39) | NPC1RAB9ALMNAMAPTKMT2A | |
| SCHEMBL5032530 | 0.82 | HTR2C (0.43) | NPC1RAB9AHTR2CTP53MAPT | |
| SCHEMBL5035249 | 0.79 | LMNA (0.38) | NPC1RAB9ALMNAMAPTKMT2A | |
| SCHEMBL5034690 | 0.79 | CNR1 (0.40) | NPC1RAB9ALMNASPTLC2KMT2A | |
| SCHEMBL27664739 | 0.77 | HTR2C (0.52) | NPC1RAB9AHTR2CLMNATP53 | |
| SCHEMBL5032649 | 0.77 | ALDH1A1 (0.48) | NPC1RAB9ALMNATSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100509808-C | Novel thiazole derivates | HOFFMANN LA ROCHE (CH) | 2009-07-08 | — | — | CN | claimed |
| CN-1890236-A | Novel thiazole derivates | HOFFMANN LA ROCHE (CH) | 2007-01-03 | — | — | CN | claimed |
| CN-100509808-C | Novel thiazole derivates | HOFFMANN LA ROCHE (CH) | 2009-07-08 | — | — | CN | disclosed |
| CN-1890236-A | Novel thiazole derivates | HOFFMANN LA ROCHE (CH) | 2007-01-03 | — | — | CN | disclosed |