Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 2/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA9 | Q16790 | 1/20 | 0.54 |
| ▸ | CHKA | P35790 | 1/20 | 0.52 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.50 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.50 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.50 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.50 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5031106 | 1.00 | CA2 (0.54) | CA2CA12CA1CA9CHKA | |
| SCHEMBL28811476 | 1.00 | CA2 (0.54) | CA2CA12CA1CA9CHKA | |
| SCHEMBL31505510 | 0.97 | CA2 (0.52) | CA2CA12CA1CA9CHKA | |
| SCHEMBL15319 | 0.97 | — | — | |
| SCHEMBL6961568 | 0.97 | — | — | |
| SCHEMBL17100538 | 0.97 | CA2 (0.56) | CA2CA12CA1CA9CHKA | |
| Water SCHEMBL10607939 | 0.94 | CA2 (0.54) | CA2CA12CA1CA9CHKA | |
| Hydrochloric Acid SCHEMBL125486 | 0.94 | CA2 (0.54) | CA2CA12CA1CA9CHKA | |
| Hydrochloric Acid SCHEMBL18116041 | 0.94 | CA2 (0.54) | CA2CA12CA1CA9CHKA | |
| Water SCHEMBL11193463 | 0.94 | CA2 (0.54) | CA2CA12CA1CA9CHKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107708840-B | Separation of CO from a gas stream 2 Method (2) | 俄亥俄州创新基金会 | 2022-12-20 | — | — | CN | disclosed |
| CN-107108637-B | Triazolopyrimidine compound and application thereof | NOVARTIS AG (CH) | 2019-10-29 | — | — | CN | disclosed |
| CN-108779123-A | Fused tetracyclic compound, its composition and purposes | 泰博生物科技有限公司 | 2018-11-09 | — | — | CN | disclosed |
| CN-108530428-A | Substituted pyrimidine derivatives and preparation method thereof and medicinal usage | 四川海思科制药有限公司 | 2018-09-14 | — | — | CN | disclosed |
| CN-108349969-A | Substituted pyrazolo [1,5-a ] pyridine compounds as RET kinase inhibitors | 阵列生物制药公司 | 2018-07-31 | — | — | CN | disclosed |
| CN-105175394-B | Compound with active anticancer | 三井有限公司 | 2018-06-08 | — | — | CN | disclosed |
| CN-108137510-A | Compound | 葛兰素史密斯克莱知识产权发展有限公司 | 2018-06-08 | — | — | CN | disclosed |
| CN-107709316-A | The benzodioxan derivative of 2 (base of 1 heteroaryl piperazine 4) methyl 1,4 as α 2C antagonists | 奥赖恩公司 | 2018-02-16 | — | — | CN | disclosed |
| CN-105555780-B | SYK inhibitors | 吉利德科学公司 | 2018-01-23 | — | — | CN | disclosed |
| CN-107556267-A | Novel thiazole derivates class compound, its preparation method, pharmaceutical composition and its pharmaceutical applications | 中国人民解放军军事医学科学院毒物药物研究所 | 2018-01-09 | — | — | CN | disclosed |
| CN-105555783-B | Include the autotaxin inhibitors of heteroaromatic rings benzyl amide ring core | 诺华股份有限公司 | 2017-12-01 | — | — | CN | disclosed |
| CN-105392787-B | For treating and preventing the azepine oxindole of respiratory syncytial virus infection | 豪夫迈·罗氏有限公司 | 2017-11-24 | — | — | CN | disclosed |
| CN-107344941-A | Tetrahydropyrazolopyrimidine compounds | 卫材R&D管理有限公司 | 2017-11-14 | — | — | CN | disclosed |
| CN-107108637-A | Triazolopyrimidine compound and application thereof | 诺华股份有限公司 | 2017-08-29 | — | — | CN | disclosed |
| CN-104507939-B | tetrahydropyrazolopyrimidine compounds | 卫材R&D管理有限公司 | 2017-07-25 | — | — | CN | disclosed |
| CN-105992766-A | Pyrrolo [3,2-C ] pyridine derivatives as TLR inhibitors | 武田药品工业株式会社 | 2016-10-05 | — | — | CN | disclosed |
| CN-1898222-A | Substituted aryl cycloalkanol derivatives and methods of their use | WYETH CORP (US) | 2007-01-17 | — | — | CN | disclosed |