Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 17/20 | 0.54 |
| ▸ | SLC6A5 | Q9Y345 | 8/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5562017 | 0.84 | SLC6A9 (0.54) | SLC6A9SLC6A5OPRM1KCNH2OPRL1 | |
| SCHEMBL5556937 | 0.84 | SLC6A9 (0.54) | SLC6A9SLC6A5OPRM1KCNH2OPRL1 | |
| SCHEMBL8286207 | 0.84 | SLC6A9 (0.54) | SLC6A9SLC6A5OPRM1KCNH2OPRL1 | |
| SCHEMBL5556935 | 0.84 | SLC6A9 (0.54) | SLC6A9SLC6A5OPRM1KCNH2OPRL1 | |
| SCHEMBL10740876 | 0.73 | SMN1; SMN2 (0.57) | SLC6A9SLC6A5OPRM1 | |
| SCHEMBL5556733 | 0.70 | SLC6A9 (1.00) | SLC6A9SLC6A5OPRM1OPRL1 | |
| SCHEMBL5556730 | 0.70 | SLC6A9 (1.00) | SLC6A9SLC6A5OPRM1OPRL1 | |
| SCHEMBL27625961 | 0.68 | SLC18A3 (0.51) | SLC6A9SLC6A5OPRM1KCNH2 | |
| SCHEMBL27719321 | 0.67 | SLC6A9 (0.50) | SLC6A9SLC6A5OPRM1KCNH2OPRL1 | |
| SCHEMBL13119224 | 0.66 | HPGD (0.53) | SLC6A9SLC6A5OPRM1KCNH2OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100467468-C | Triaza-spiropiperidine derivatives for use as GLYT-1 inhibitors in the treatment of neurological and neuropsychiatric disorders | HOFFMANN LA ROCHE (CH) | 2009-03-11 | — | — | CN | disclosed |
| CN-1871238-A | Triaza-spiropiperidine derivatives for use as GLYT-1 inhibitors in the treatment of neurological and neuropsychiatric disorders | HOFFMANN LA ROCHE (CH) | 2006-11-29 | — | — | CN | disclosed |