Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLRA1 | P23415 | 1/20 | 0.67 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.67 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.67 |
| ▸ | FFAR3 | O14843 | 3/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | FYN | P06241 | 1/20 | 0.47 |
| ▸ | GABRR1 | P24046 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 6/20 | 0.38 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.38 |
| ▸ | KDM6B | O15054 | 1/20 | 0.38 |
| ▸ | KDM5C | P41229 | 1/20 | 0.38 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.38 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 3/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycine SCHEMBL20854478 | 0.97 | GLRA1 (0.71) | GLRA1SLC6A9OR51E2FFAR3LCK | |
| Glycine SCHEMBL3343294 | 0.97 | GLRA1 (0.71) | GLRA1SLC6A9OR51E2FFAR3LCK | |
| Glycine SCHEMBL28881593 | 0.97 | GLRA1 (0.71) | GLRA1SLC6A9OR51E2FFAR3LCK | |
| Glycine SCHEMBL28195362 | 0.93 | GLRA1 (0.67) | GLRA1SLC6A9OR51E2FFAR3LCK | |
| Glycine SCHEMBL907052 | 0.93 | GLRA1 (0.77) | GLRA1SLC6A9OR51E2FFAR3LCK | |
| Glycine SCHEMBL7918812 | 0.93 | GLRA1 (0.77) | GLRA1SLC6A9OR51E2FFAR3LCK | |
| Glycine SCHEMBL318020 | 0.93 | — | — | |
| Glycine SCHEMBL11291516 | 0.93 | GLRA1 (0.77) | GLRA1SLC6A9OR51E2FFAR3LCK | |
| Glycine SCHEMBL29244710 | 0.93 | GLRA1 (0.77) | GLRA1SLC6A9OR51E2FFAR3LCK | |
| Glycine SCHEMBL1285648 | 0.90 | GLRA1 (0.71) | GLRA1SLC6A9OR51E2FFAR3LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1911900-A | Method for preparing aminotrisodium acetate using by product hydrocyanic acid of acrylonitrile device | ZIBO WANCHANG SCIENCE AND TECH (CN) | 2007-02-14 | — | — | CN | disclosed |