Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.40 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.39 |
| ▸ | P4HB | P07237 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 3/20 | 0.39 |
| ▸ | RXRB | P28702 | 3/20 | 0.39 |
| ▸ | RXRG | P48443 | 3/20 | 0.39 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.39 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.38 |
| ▸ | TTR | P02766 | 1/20 | 0.38 |
| ▸ | ADH5 | P11766 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PLA2G2D | Q9UNK4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1697891 | 0.87 | EPHX2 (0.44) | PTPN1GSK3BEPHX2SRD5A2P4HB | |
| SCHEMBL27927540 | 0.86 | PTPN1 (0.40) | PTPN1GSK3BEPHX2 | |
| SCHEMBL16121258 | 0.83 | ACE2 (0.53) | EPHX2SRD5A2P4HBRXRARXRB | |
| SCHEMBL27682643 | 0.82 | NOTUM (0.58) | EPHX2P4HBMRGPRX4ALDH1A1 | |
| SCHEMBL6293963 | 0.81 | ALDH1A1 (0.46) | EPHX2SRD5A2P4HBRXRARXRB | |
| SCHEMBL7842202 | 0.81 | S1PR1 (0.48) | PLA2G2D | |
| SCHEMBL17831713 | 0.81 | PDE3B (0.44) | EPHX2SRD5A2P4HBRXRARXRB | |
| SCHEMBL9184815 | 0.80 | EPHX2 (0.41) | EPHX2SRD5A2P4HBRXRARXRB | |
| SCHEMBL27605598 | 0.80 | CA12 (0.47) | EPHX2ALDH1A1 | |
| SCHEMBL27720459 | 0.79 | PTPN1 (0.37) | PTPN1GSK3BEPHX2SRD5A2RXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104844566-B | A kind of kinase inhibitor of new structure | 合肥中科普瑞昇生物医药科技有限公司 | 2018-05-18 | — | — | CN | disclosed |
| CN-105143209-A | Biaryl amide compounds as kinase inhibitors | NOVARTIS AG | 2015-12-09 | — | — | CN | disclosed |
| CN-105008354-A | Protein kinase inhibitors | ORIBASE PHARMA | 2015-10-28 | — | — | CN | disclosed |
| CN-102421754-B | Acrylamide derivative and use thereof in manufacture of medicament | BEIJING SHIQIAO BIOPHAM CO LTD | 2013-11-27 | — | — | CN | disclosed |
| CN-101456841-B | Amide derivative and medicine | NIPPON SHINYAKU CO LTD | 2012-01-25 | — | — | CN | disclosed |
| CN-101696188-A | Trifluoromethyl substituted benzamides as kinase inhibitors | NOVARTIS AG | 2010-04-21 | — | — | CN | disclosed |
| CN-100526298-C | Amide derivative and pharmaceutical | NIPPON SHINYAKU CO LTD (JP) | 2009-08-12 | — | — | CN | disclosed |
| CN-101456841-A | Amide derivative and medicine | NIPPON SHINYAKU CO LTD (JP) | 2009-06-17 | — | — | CN | disclosed |
| CN-101039914-A | Trifluoromethyl substituted benzamide compounds as kinase inhibitors | NOVARTIS AG (CH) | 2007-09-19 | — | — | CN | disclosed |
| CN-1898208-A | Amide derivative and pharmaceutical | NIPPON SHINYAKU CO LTD (JP) | 2007-01-17 | — | — | CN | disclosed |