Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.36 |
| ▸ | GABRR2 | P28476 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.36 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13134160 | 0.77 | MEN1 (0.40) | HRH4HRH3CYP3A4ALDH1A1TSHR | |
| SCHEMBL19974645 | 0.75 | MEN1 (0.38) | HRH3CYP3A4ALDH1A1TSHRGABRA1 | |
| SCHEMBL19974760 | 0.73 | HRH3 (0.40) | HRH4HRH3CYP3A4ALDH1A1TSHR | |
| SCHEMBL3961101 | 0.72 | — | — | |
| SCHEMBL7158594 | 0.71 | — | — | |
| SCHEMBL8521326 | 0.70 | HCAR2 (0.38) | ALDH1A1 | |
| SCHEMBL13134162 | 0.69 | KMT2A (0.36) | HRH3CYP3A4ALDH1A1TSHRGABRA1 | |
| SCHEMBL19974692 | 0.68 | HRH4 (0.45) | HRH4HRH3ALDH1A1MAPT | |
| SCHEMBL19974661 | 0.68 | MEN1 (0.41) | HRH3CYP3A4ALDH1A1TSHRGABRA1 | |
| SCHEMBL11871532 | 0.68 | HTT (0.34) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1886407-A | Bicyclic pyrazolyl and imidazolyl compounds and uses thereof | PFIZER (US) | 2006-12-27 | — | — | CN | disclosed |