Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F11 | P03951 | 20/20 | 0.81 |
| ▸ | KLKB1 | P03952 | 19/20 | 0.81 |
| ▸ | F10 | P00742 | 2/20 | 0.81 |
| ▸ | F7 | P08709 | 2/20 | 0.59 |
| ▸ | F12 | P00748 | 1/20 | 0.58 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.58 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.58 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL393092 | 1.00 | F11 (0.81) | F11KLKB1F10F7F12 | |
| SCHEMBL393093 | 1.00 | F11 (0.81) | F11KLKB1F10F7F12 | |
| SCHEMBL392751 | 0.88 | F11 (0.81) | F11KLKB1F10F7F12 | |
| SCHEMBL392750 | 0.88 | F11 (0.81) | F11KLKB1F10F7F12 | |
| SCHEMBL393831 | 0.88 | F11 (0.92) | F11KLKB1F10F7F12 | |
| SCHEMBL392450 | 0.88 | F11 (0.81) | F11KLKB1F10F7F12 | |
| SCHEMBL392451 | 0.88 | F11 (0.81) | F11KLKB1F10F7F12 | |
| SCHEMBL394819 | 0.87 | F11 (0.74) | F11KLKB1F10 | |
| SCHEMBL394818 | 0.87 | F11 (0.74) | F11KLKB1F10 | |
| SCHEMBL392445 | 0.87 | F11 (0.63) | F11KLKB1F10F7F12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101006063-B | Five-membered heterocycles useful as serine protease inhibitors. | BRISTOL MYERS SQUIBB CO | 2013-07-17 | — | — | CN | disclosed |
| CN-101006063-A | Five-membered heterocycles useful as serine protease inhibitors. | BRISTOL MYERS SQUIBB CO (US) | 2007-07-25 | — | — | CN | disclosed |