Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 8/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2767400 | 0.88 | LMNA (0.46) | LMNAPOLBMAPTTP53ALDH1A1 | |
| SCHEMBL3284662 | 0.86 | LMNA (0.54) | LMNAPOLBMAPTTP53ALDH1A1 | |
| SCHEMBL13326796 | 0.86 | LMNA (0.54) | LMNAPOLBMAPTTP53ALDH1A1 | |
| SCHEMBL2766124 | 0.84 | LMNA (0.44) | LMNAPOLBMAPTTP53KDM4E | |
| SCHEMBL2765569 | 0.83 | LMNA (0.46) | LMNAPOLBMAPTTP53KDM4E | |
| SCHEMBL2767137 | 0.83 | LMNA (0.46) | LMNAPOLBMAPTTP53KDM4E | |
| SCHEMBL2766335 | 0.80 | LMNA (0.45) | LMNAPOLBMAPTTP53ALDH1A1 | |
| SCHEMBL2767397 | 0.79 | LMNA (0.44) | LMNAPOLBMAPTTP53 | |
| SCHEMBL2767344 | 0.79 | POLB (0.41) | LMNAPOLBMAPTTP53ALDH1A1 | |
| SCHEMBL2765159 | 0.79 | POLB (0.41) | LMNAPOLBMAPTTP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1858890-B1 | NOVEL ANTITHROMBOTIC SUBSTITUTED PYRROLIDINONES, THE PRODUCTION AND USE THEREOF IN THE FORM OF MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA (DE) | 2010-04-14 | — | — | EP | disclosed |