Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 1/20 | 0.48 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.47 |
| ▸ | EP300 | Q09472 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | DDX3X | O00571 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27693487 | 0.88 | LMNA (0.51) | CREBBPEP300MAOBKDM4ELMNA | |
| SCHEMBL27675135 | 0.87 | CREBBP (0.54) | CREBBPEP300MAOBKDM4ELMNA | |
| SCHEMBL27693567 | 0.87 | CREBBP (0.47) | CREBBPEP300MAOBKDM4ELMNA | |
| SCHEMBL27693586 | 0.86 | MAOB (0.60) | CREBBPEP300MAOBKDM4ELMNA | |
| SCHEMBL27675196 | 0.86 | CREBBP (0.52) | CREBBPEP300MAOBLMNACHRM1 | |
| SCHEMBL27675238 | 0.85 | MAOB (0.44) | CREBBPMAOBKDM4ELMNACHRM1 | |
| SCHEMBL27693516 | 0.85 | CREBBP (0.61) | CREBBPEP300MAOBKDM4E | |
| SCHEMBL27675089 | 0.84 | CA1 (0.51) | CREBBPEP300KDM4EALDH1A1 | |
| SCHEMBL27693473 | 0.84 | LMNA (0.50) | CREBBPEP300MAOBLMNACHRM1 | |
| SCHEMBL27693534 | 0.84 | MAOB (0.50) | CREBBPEP300MAOBKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101006076-B | Modulators of ATP-binding cassette transporters | VERTEX PHARMA | 2010-09-29 | — | — | CN | disclosed |
| CN-101006076-A | Modulators of ATP-binding cassette transporters | VERTEX PHARMA (US) | 2007-07-25 | — | — | CN | disclosed |