Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Threonine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.41 |
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.41 |
| ▸ | LAP3 | P28838 | 2/20 | 0.40 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.38 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.37 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.37 |
| ▸ | GLUL | P15104 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Threonine SCHEMBL103943 | 0.92 | USP2 (0.47) | USP2SLCO1B1SLC7A5SLC1A1SLC1A3 | |
| Threonine SCHEMBL7730685 | 0.92 | USP2 (0.47) | USP2SLCO1B1SLC7A5SLC1A1SLC1A3 | |
| Threonine SCHEMBL9139632 | 0.92 | USP2 (0.47) | USP2SLCO1B1SLC7A5SLC1A1SLC1A3 | |
| Threonine SCHEMBL1537268 | 0.92 | USP2 (0.47) | USP2SLCO1B1SLC7A5SLC1A1SLC1A3 | |
| Threonine SCHEMBL9139658 | 0.92 | USP2 (0.47) | USP2SLCO1B1SLC7A5SLC1A1SLC1A3 | |
| Threonine SCHEMBL27468644 | 0.92 | USP2 (0.47) | USP2SLCO1B1SLC7A5SLC1A1SLC1A3 | |
| Threonine SCHEMBL1537265 | 0.92 | USP2 (0.47) | USP2SLCO1B1SLC7A5SLC1A1SLC1A3 | |
| Threonine SCHEMBL103941 | 0.92 | USP2 (0.47) | USP2SLCO1B1SLC7A5SLC1A1SLC1A3 | |
| Threonine SCHEMBL5710205 | 0.92 | USP2 (0.47) | USP2SLCO1B1SLC7A5SLC1A1SLC1A3 | |
| Threonine SCHEMBL1067383 | 0.89 | USP2 (0.44) | USP2SLCO1B1SLC7A5SLC1A1SLC1A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106619600-B | The application of ingenol and its derivative in enhancing lysosome generates | 中国科学院遗传与发育生物学研究所 | 2019-10-18 | — | — | CN | disclosed |
| CN-1894278-B | Polypeptide for specifically inhibiting Akt activity | JAPAN SCIENCE & TECH AGENCY | 2011-09-21 | — | — | CN | disclosed |
| CN-1894278-A | Polypeptide for specifically inhibiting Akt activity | JAPAN SCIENCE & TECH AGENCY (JP) | 2007-01-10 | — | — | CN | disclosed |