Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 3/20 | 0.60 |
| ▸ | KIT | P10721 | 2/20 | 0.60 |
| ▸ | MET | P08581 | 3/20 | 0.58 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.57 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.51 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 2/20 | 0.42 |
| ▸ | HTR6 | P50406 | 2/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1267285 | 0.88 | MET (0.58) | CSF1RKITMETGPR84FGFR1 | |
| SCHEMBL13861701 | 0.88 | MET (0.58) | CSF1RKITMETGPR84FGFR1 | |
| SCHEMBL1267499 | 0.86 | CSF1R (0.64) | CSF1RKITMETGPR84FGFR1 | |
| SCHEMBL12898207 | 0.86 | CSF1R (0.53) | CSF1RKITMETGPR84FGFR1 | |
| SCHEMBL1266551 | 0.85 | CSF1R (0.52) | CSF1RKITMETGPR84FGFR1 | |
| SCHEMBL2180664 | 0.85 | CSF1R (0.52) | CSF1RKITMETGPR84FGFR1 | |
| SCHEMBL27708251 | 0.85 | CSF1R (0.52) | CSF1RKITMETGPR84FGFR1 | |
| SCHEMBL12303973 | 0.85 | CSF1R (0.55) | CSF1RKITMETGPR84FGFR1 | |
| SCHEMBL1267902 | 0.84 | CSF1R (0.54) | CSF1RKITMETGPR84FGFR1 | |
| SCHEMBL18400507 | 0.84 | CSF1R (0.64) | CSF1RKITMETGPR84FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1925855-B | Compounds and methods for development of Ret modulators | PLEXXIKON INC | 2010-06-16 | — | — | CN | disclosed |
| CN-1925855-A | Compounds and methods for development of Ret modulators | PLEXXIKON INC (US) | 2007-03-07 | — | — | CN | disclosed |