Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.40 |
| ▸ | GRIN2D | O15399 | 4/20 | 0.35 |
| ▸ | GRIN3B | O60391 | 4/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.35 |
| ▸ | GRIN2A | Q12879 | 4/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.35 |
| ▸ | GRIN2C | Q14957 | 4/20 | 0.35 |
| ▸ | GRIN3A | Q8TCU5 | 4/20 | 0.35 |
| ▸ | BPTF | Q12830 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | GBA1 | P04062 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28223160 | 0.68 | KDM4E (0.58) | KDM4ECYP11B1CYP11B2GRIN2DGRIN3B | |
| SCHEMBL6313788 | 0.68 | KDM4E (0.58) | KDM4ECYP11B1CYP11B2GRIN2DGRIN3B | |
| SCHEMBL24352139 | 0.68 | KDM4E (0.96) | KDM4ECYP11B1CYP11B2GRIN2DGRIN3B | |
| SCHEMBL6313783 | 0.68 | KDM4E (0.58) | KDM4ECYP11B1CYP11B2GRIN2DGRIN3B | |
| SCHEMBL6313781 | 0.67 | KDM4E (0.56) | KDM4ECYP11B1CYP11B2GRIN2DGRIN3B | |
| SCHEMBL7853978 | 0.66 | KDM4E (0.50) | KDM4ECYP11B1CYP11B2GRIN2DGRIN3B | |
| SCHEMBL248319 | 0.60 | — | — | |
| SCHEMBL1199990 | 0.60 | — | — | |
| SCHEMBL19173447 | 0.60 | KDM4E (0.47) | KDM4EHSD11B1EPHX2ALDH1A1L3MBTL1 | |
| SCHEMBL21244858 | 0.59 | POLB (0.46) | KDM4ECYP11B1CYP11B2BPTFEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101001851-B | Hydroxyamide compounds having activity as inhibitors of histone deacetylase (HDAC) | ASTELLAS PHARMA INC | 2011-04-20 | — | — | CN | disclosed |
| CN-101001851-A | Hydroxyamide compounds having activity as inhibitors of histone deacetylase (HDAC) | ASTELLAS PHARMA INC (JP) | 2007-07-18 | — | — | CN | disclosed |