Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | IDO1 | P14902 | 2/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.31 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.31 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23997494 | 0.81 | HRH3 (0.38) | MTNR1AMTNR1B | |
| SCHEMBL23997326 | 0.81 | RAB9A (0.42) | IDO1MTNR1AMTNR1BSMN1; SMN2NPC1 | |
| SCHEMBL9494 | 0.80 | RAB9A (0.47) | SMN1; SMN2NOTUMNPC1HPGDTSHR | |
| SCHEMBL25281776 | 0.72 | MAPK1 (0.42) | CYP3A4SMN1; SMN2LMNATP53TSHR | |
| SCHEMBL5491719 | 0.68 | CYP3A4 (0.50) | CYP3A4IDO1APPTSHR | |
| SCHEMBL25418048 | 0.68 | NOTUM (0.35) | NOTUM | |
| SCHEMBL3685411 | 0.65 | NOTUM (0.64) | LMNATP53NOTUMNPC1HPGD | |
| SCHEMBL23997423 | 0.64 | MAPT (0.35) | APPNOTUM | |
| SCHEMBL2752802 | 0.63 | NPC1 (0.46) | SMN1; SMN2LMNANPC1RAB9A | |
| SCHEMBL19851469 | 0.63 | MEN1 (0.33) | CYP3A4IDO1SMN1; SMN2LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1938273-B | Tetrahydrocarbazoles and derivatives | HOFFMAN-LA ROCHE LTD. (CH) | 2011-12-14 | — | — | CN | disclosed |
| CN-1938273-A | Tetrahydrocarbazoles and derivatives | HOFFMANN LA ROCHE (CH) | 2007-03-28 | — | — | CN | disclosed |