Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.31 |
| ▸ | FEN1 | P39748 | 1/20 | 0.31 |
| ▸ | FBP1 | P09467 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL744062 | 0.85 | CES1 (0.38) | CES1P2RY2ALOX15TSHRKDM4E | |
| SCHEMBL18782175 | 0.81 | HCAR2 (0.42) | CES1P2RY2ALOX15TSHRKDM4E | |
| SCHEMBL18782173 | 0.81 | CES1 (0.39) | CES1P2RY2ALOX15TSHRKDM4E | |
| SCHEMBL16011738 | 0.81 | CES1 (0.39) | CES1P2RY2ALOX15TSHRKDM4E | |
| SCHEMBL15931723 | 0.79 | HCAR2 (0.45) | CES1ALOX15TSHRKDM4ETDP1 | |
| SCHEMBL742811 | 0.79 | CES1 (0.39) | CES1P2RY2ALOX15TSHRKDM4E | |
| SCHEMBL27603649 | 0.77 | CYP1A2 (0.46) | TSHRKDM4EFBP1ALDH1A1 | |
| SCHEMBL3590995 | 0.77 | CES1 (0.38) | CES1P2RY2ALOX15TSHRKDM4E | |
| SCHEMBL1972922 | 0.77 | CES1 (0.38) | CES1P2RY2ALOX15TSHRKDM4E | |
| SCHEMBL1811036 | 0.77 | CES1 (0.38) | CES1P2RY2ALOX15TSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1938273-B | Tetrahydrocarbazoles and derivatives | HOFFMAN-LA ROCHE LTD. (CH) | 2011-12-14 | — | — | CN | disclosed |
| CN-1938273-A | Tetrahydrocarbazoles and derivatives | HOFFMANN LA ROCHE (CH) | 2007-03-28 | — | — | CN | disclosed |