Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | FBP1 | P09467 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1811036 | 0.82 | CES1 (0.38) | CES1KDM4EALOX15TSHRACMSD | |
| SCHEMBL344751 | 0.82 | ALDH1A1 (0.47) | TSHRHDAC6LMNAALDH1A1FBP1 | |
| SCHEMBL1166830 | 0.82 | FPR2 (0.42) | HDAC6ALDH1A1HRH3 | |
| SCHEMBL3590995 | 0.82 | CES1 (0.38) | CES1KDM4EALOX15TSHRACMSD | |
| SCHEMBL1972922 | 0.82 | CES1 (0.38) | CES1KDM4EALOX15TSHRACMSD | |
| SCHEMBL1760523 | 0.82 | HCAR2 (0.39) | CES1HCAR2KDM4EALOX15TSHR | |
| SCHEMBL744062 | 0.82 | CES1 (0.38) | CES1KDM4EALOX15TSHRACMSD | |
| SCHEMBL18782173 | 0.79 | CES1 (0.39) | CES1KDM4EALOX15TSHRACMSD | |
| SCHEMBL16011738 | 0.79 | CES1 (0.39) | CES1KDM4EALOX15TSHRACMSD | |
| SCHEMBL18782175 | 0.79 | HCAR2 (0.42) | CES1HCAR2KDM4EALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250101032-A1 | EXATECAN DERIVATIVES AND ANTIBODY-DRUG CONJUGATES THEREOF | ALX Oncology Inc. | 2025-03-27 | — | — | US | disclosed |
| CN-118251395-A | Esatitecan derivatives and antibody-drug conjugates thereof | ALX肿瘤学股份有限公司 | 2024-06-25 | — | — | CN | disclosed |
| EP-4334322-A1 | EXATECAN DERIVATIVES AND ANTIBODY-DRUG CONJUGATES THEREOF | ALX Oncology Inc. (US) | 2024-03-13 | — | — | EP | disclosed |
| CN-117486873-A | Fluorophenyl piperidone compound and derivative and pharmaceutical application thereof | 中国人民解放军空军军医大学 | 2024-02-02 | — | — | CN | disclosed |
| WO-2022236136-A1 | EXATECAN DERIVATIVES AND ANTIBODY-DRUG CONJUGATES THEREOF | ALX Oncology Inc. (US) | 2022-11-10 | — | — | WO | disclosed |
| CN-102414207-B | Fluorinated aminotriazole derivatives | ACTELION PHARMACEUTICALS LTD. (CH) | 2015-09-30 | — | — | CN | disclosed |
| EP-2430006-B1 | CYCLOPENTA[C]PYRROLE-2-CARBOXYLATE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI SA (FR) | 2014-11-26 | — | — | EP | disclosed |
| CN-102803237-B | Oxazole and thiazole derivatives as alx receptor agonists | ACTELION PHARMACEUTICALS LTD | 2014-09-24 | — | — | CN | disclosed |
| CN-101903353-B | Aminopyrazole derivatives | ACTELION PHARMACEUTICALS LTD | 2013-04-10 | — | — | CN | disclosed |
| CN-102803237-A | Oxazole and thiazole derivatives as alx receptor agonists | ACTELION PHARMACEUTICALS LTD | 2012-11-28 | — | — | CN | disclosed |
| CN-102414207-A | Fluorinated aminotriazole derivatives | ACTELION PHARMACEUTICALS LTD | 2012-04-11 | — | — | CN | disclosed |
| EP-2430006-A1 | CYCLOPENTA[C]PYRROLE-2-CARBOXYLATE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-21 | — | — | EP | disclosed |
| CN-101903353-A | Aminopyrazole derivatives | ACTELION PHARMACEUTICALS LTD | 2010-12-01 | — | — | CN | disclosed |
| WO-2010130944-A1 | CYCLOPENTA[C]PYRROLE-2-CARBOXYLATE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-11-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250101032-A1 | EXATECAN DERIVATIVES AND ANTIBODY-DRUG CONJUGATES THEREOF | CTSB, CTSE, CTSD | CES1 680/4885HCAR2 1493/4885KDM4E 1224/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.