Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 6/20 | 0.51 |
| ▸ | CDK8 | P49336 | 3/20 | 0.51 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | KIT | P10721 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | SGK1 | O00141 | 3/20 | 0.43 |
| ▸ | CLK1 | P49759 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.43 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.43 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1800807 | 0.82 | AXL (0.73) | AXLCDK8TNIKGSK3BKIT | |
| SCHEMBL12829259 | 0.74 | NTRK1 (0.66) | AXLCDK8TNIKGSK3BBRD4 | |
| SCHEMBL20408723 | 0.74 | KIT (0.59) | AXLCDK8TNIKGSK3BBRD4 | |
| SCHEMBL8320542 | 0.74 | DYRK1A (0.59) | AXLCDK8TNIKGSK3BBRD4 | |
| SCHEMBL8320268 | 0.73 | KIT (0.61) | AXLCDK8TNIKGSK3BBRD4 | |
| SCHEMBL17939084 | 0.73 | AXL (0.71) | AXLCDK8TNIKGSK3BBRD4 | |
| SCHEMBL27699368 | 0.72 | CDK8 (0.67) | AXLCDK8GSK3BBRD4NTRK1 | |
| SCHEMBL12829859 | 0.70 | CDK8 (0.60) | AXLCDK8TNIKGSK3BBRD4 | |
| SCHEMBL8320227 | 0.70 | KIT (0.67) | KITDYRK1A | |
| SCHEMBL8320264 | 0.70 | AXL (0.52) | AXLCDK8TNIKGSK3BBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101027302-B | Pyrrolo-pyridine kinase modulators | SGX PHARMACEUTICALS INC | 2011-05-11 | — | — | CN | disclosed |
| CN-101027302-A | Pyrrolo-pyridine kinase modulators | SGX PHARMACEUTICALS INC (US) | 2007-08-29 | — | — | CN | disclosed |