Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 2/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.47 |
| ▸ | TRPA1 | O75762 | 4/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.40 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27680631 | 1.00 | AOC3 (0.47) | AOC3TAAR1TRPA1RIPK1GRIA4 | |
| SCHEMBL27797487 | 1.00 | AOC3 (0.47) | AOC3TAAR1TRPA1RIPK1GRIA4 | |
| SCHEMBL1031364 | 0.87 | TAAR1 (0.58) | AOC3TAAR1TRPA1RIPK1ALDH1A1 | |
| SCHEMBL1416410 | 0.87 | TAAR1 (0.58) | AOC3TAAR1TRPA1RIPK1ALDH1A1 | |
| SCHEMBL1033147 | 0.87 | TAAR1 (0.58) | AOC3TAAR1TRPA1RIPK1ALDH1A1 | |
| SCHEMBL27699812 | 0.82 | HDAC4 (0.49) | AOC3TAAR1TRPA1RIPK1GRIA4 | |
| SCHEMBL28751353 | 0.82 | TAAR1 (0.48) | AOC3TAAR1TRPA1RIPK1GRIA4 | |
| SCHEMBL27548676 | 0.80 | TAAR1 (0.47) | AOC3TAAR1TRPA1RIPK1GRIA4 | |
| SCHEMBL1027356 | 0.78 | ALDH1A1 (0.40) | GRIA4ALDH1A1LMNA | |
| SCHEMBL1031298 | 0.78 | ALDH1A1 (0.40) | GRIA4ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103073460-A | Arylsulfonylmethyl or arylsulfonamide substituted aromatic compounds suitable for treating disorders that respond to modulation of the dopamine D3 receptor | ABBOTT GMBH & CO KG | 2013-05-01 | — | — | CN | disclosed |
| CN-101068801-B | Arylsulfonylmethyl or arylsulfonamide substituted aromatic compounds suitable for the treatment of disorders which respond to modulation of the dopamine D3 receptor | ABBOTT GMBH & CO KG | 2012-11-14 | — | — | CN | disclosed |
| CN-101421243-B | Aryloxyethylamine compounds suitable for treating disorders that respond to modulation of the dopamine D3 receptor | ABBOTT GMBH & CO KG | 2012-05-30 | — | — | CN | disclosed |
| CN-101039900-B | 6-amino(aza)indane compounds suitable for treating disorders that respond to modulation of the dopamine d3 receptor | ABBOTT GMBH & CO KG | 2012-03-21 | — | — | CN | disclosed |
| CN-101421243-A | Aryloxyethylamine compounds suitable for treating disorders that respond to modulation of the dopamine D3 receptor | ABBOTT GMBH & CO KG (DE) | 2009-04-29 | — | — | CN | disclosed |
| CN-101068801-A | Arylsulfonylmethyl or arylsulfonamide substituted aromatic compounds suitable for the treatment of disorders which respond to modulation of the dopamine D3 receptor | ABBOTT GMBH & CO KG (DE) | 2007-11-07 | — | — | CN | disclosed |
| CN-101039904-A | Is suitable for treating dopamine D3Heterocyclic compounds for receptor-modulated responsive disorders | ABBOTT GMBH & CO KG (DE) | 2007-09-19 | — | — | CN | disclosed |
| CN-101039900-A | 6-amino(aza)indane compounds suitable for treating disorders that respond to modulation of the dopamine d3 receptor | ABBOTT GMBH & CO KG (DE) | 2007-09-19 | — | — | CN | disclosed |