SCHEMBL27680972

SCHEMBL27680972

Cc1cc(C(=O)O)nc(N2CCC(O)C2)n1

nearest known ligand 0.54

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
RBP4 P02753 16/20 0.54
TTR P02766 11/20 0.54
KDM4E B2RXH2 2/20 0.54
HSD17B10 Q99714 2/20 0.54
USP2 O75604 1/20 0.54
HPGD P15428 1/20 0.54
NPSR1 Q6W5P4 1/20 0.54
MEN1 O00255 1/20 0.52
ALDH1A1 P00352 1/20 0.52
KMT2A Q03164 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27680981 0.92 KDM4E (0.60) RBP4TTRKDM4EHSD17B10USP2
SCHEMBL13494044 0.82 KDM4E (0.81) RBP4TTRKDM4EHSD17B10USP2
SCHEMBL31539367 0.81 KDM4E (0.47) RBP4TTRKDM4EHSD17B10USP2
SCHEMBL27681034 0.80 RBP4 (0.56) RBP4TTRKDM4EHSD17B10USP2
SCHEMBL1179851 0.79 RBP4 (0.59) RBP4TTRKDM4EHSD17B10USP2
SCHEMBL30637298 0.78 RBP4 (0.64) RBP4TTRKDM4EHSD17B10USP2
SCHEMBL12552670 0.78 RBP4 (0.55) RBP4TTRKDM4EHSD17B10USP2
SCHEMBL27681017 0.78 RBP4 (0.61) RBP4TTRKDM4EHSD17B10MEN1
SCHEMBL5216228 0.78 RBP4 (0.57) RBP4TTRKDM4EHSD17B10USP2
SCHEMBL6396185 0.77 RBP4 (0.69) RBP4TTRKDM4EHSD17B10USP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101023063-A Azine-carboxamides as anti-cancer agents ASTRAZENECA AB (SE) 2007-08-22 CN disclosed