Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 9/20 | 0.54 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.47 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.46 |
| ▸ | KDM5A | P29375 | 1/20 | 0.46 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
| ▸ | HSD17B13 | Q7Z5P4 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.42 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3524048 | 0.91 | KDM4E (0.48) | MMP13KDM4EALDH1A1L3MBTL1MAPK14 | |
| SCHEMBL3523270 | 0.89 | MAPK14 (0.49) | MMP13KDM4CKDM5AKDM5BKDM4E | |
| SCHEMBL28783619 | 0.82 | ALDH1A1 (0.52) | MMP13PTGER4KDM4CKDM5AKDM5B | |
| SCHEMBL3523863 | 0.81 | GRIN1 (0.44) | MMP13KDM4EALDH1A1MAPK14LMNA | |
| SCHEMBL3526199 | 0.81 | HSD17B13 (0.52) | MMP13KDM4EALDH1A1L3MBTL1MAPK14 | |
| SCHEMBL3523859 | 0.81 | MAPK14 (0.57) | MMP13KDM4EALDH1A1L3MBTL1MAPK14 | |
| SCHEMBL3522187 | 0.79 | MAPK14 (0.48) | MMP13KDM4EALDH1A1L3MBTL1MAPK14 | |
| SCHEMBL3520420 | 0.78 | MAPK14 (0.48) | MMP13KDM4EMAPK14HSD17B13LMNA | |
| SCHEMBL3520013 | 0.78 | MAPT (0.53) | MMP13KDM4EALDH1A1L3MBTL1MAPK14 | |
| SCHEMBL3525849 | 0.78 | MAPK14 (0.46) | MMP13KDM4EMAPK14LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1968937-A | Pyrimidin-4-one derivatives and their use as P38 kinase modulators | PHARMACIA CORP (US) | 2007-05-23 | — | — | CN | disclosed |