Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 4/20 | 0.68 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.67 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.59 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.59 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.59 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.59 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.59 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | RECQL | P46063 | 1/20 | 0.58 |
| ▸ | HTR1B | P28222 | 2/20 | 0.58 |
| ▸ | HTR1D | P28221 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | DRD2 | P14416 | 2/20 | 0.53 |
| ▸ | DRD3 | P35462 | 2/20 | 0.53 |
| ▸ | MLNR | O43193 | 1/20 | 0.53 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.53 |
| ▸ | ESR1 | P03372 | 1/20 | 0.53 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.53 |
| ▸ | PGR | P06401 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14134168 | 1.00 | LTA4H (0.68) | LTA4HKCNA3CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL144684 | 1.00 | LTA4H (0.68) | LTA4HKCNA3CHRNB2CHRNB4CHRNA3 | |
| Water SCHEMBL28227627 | 0.97 | LTA4H (0.65) | LTA4HKCNA3CHRNB2CHRNB4CHRNA3 | |
| Ammonia Solution, Strong SCHEMBL366156 | 0.97 | LTA4H (0.65) | LTA4HKCNA3CHRNB2CHRNB4CHRNA3 | |
| Methane SCHEMBL27606132 | 0.97 | LTA4H (0.65) | LTA4HKCNA3CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL27872707 | 0.95 | LTA4H (0.63) | LTA4HKCNA3CHRNB2CHRNB4CHRNA3 | |
| Methylamine SCHEMBL27799293 | 0.95 | LTA4H (0.63) | LTA4HKCNA3CHRNB2CHRNB4CHRNA3 | |
| Hydrochloric Acid SCHEMBL28934584 | 0.95 | LTA4H (0.63) | LTA4HKCNA3CHRNB2CHRNB4CHRNA3 | |
| Phenetole SCHEMBL9011910 | 0.93 | LTA4H (0.65) | LTA4HKCNA3CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL2276426 | 0.91 | LTA4H (0.59) | LTA4HKCNA3CHRNB2CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101531631-B | Substituted pyridinones as modulators of p38 map kinase | PHARMACIA CORP | 2011-09-28 | — | — | CN | disclosed |
| CN-101531631-A | Substituted pyridinones as modulators of p38 map kinase | PHARMACIA CORP (US) | 2009-09-16 | — | — | CN | disclosed |
| CN-1968937-A | Pyrimidin-4-one derivatives and their use as P38 kinase modulators | PHARMACIA CORP (US) | 2007-05-23 | — | — | CN | disclosed |