Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 9/20 | 0.39 |
| ▸ | CHUK | O15111 | 8/20 | 0.39 |
| ▸ | JAK2 | O60674 | 9/20 | 0.39 |
| ▸ | JAK3 | P52333 | 9/20 | 0.39 |
| ▸ | JAK1 | P23458 | 2/20 | 0.37 |
| ▸ | TYK2 | P29597 | 2/20 | 0.37 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | PLK1 | P53350 | 1/20 | 0.30 |
| ▸ | BTK | Q06187 | 1/20 | 0.30 |
| ▸ | ITK | Q08881 | 1/20 | 0.30 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2768404 | 0.83 | JAK2 (0.42) | IKBKBCHUKJAK2JAK3JAK1 | |
| SCHEMBL3550355 | 0.82 | IKBKB (0.44) | IKBKBCHUKJAK2JAK3JAK1 | |
| SCHEMBL2766408 | 0.79 | IKBKB (0.50) | IKBKBCHUKJAK2JAK3JAK1 | |
| SCHEMBL2766181 | 0.77 | JAK2 (0.52) | IKBKBCHUKJAK2JAK3JAK1 | |
| SCHEMBL3040915 | 0.77 | JAK2 (0.42) | IKBKBCHUKJAK2JAK3JAK1 | |
| SCHEMBL2768039 | 0.77 | IKBKB (0.43) | IKBKBCHUKJAK2JAK3JAK1 | |
| SCHEMBL2766249 | 0.77 | IKBKB (0.43) | IKBKBCHUKJAK2JAK3JAK1 | |
| SCHEMBL2767822 | 0.76 | JAK2 (0.46) | IKBKBCHUKJAK2JAK3JAK1 | |
| SCHEMBL2768229 | 0.76 | IKBKB (0.46) | IKBKBCHUKJAK2JAK3JAK1 | |
| SCHEMBL2768209 | 0.76 | JAK2 (0.48) | IKBKBCHUKJAK2JAK3JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888584-B1 | 1, 6 -DIHYDRO- 1,3, 5, 6-TETRAAZA-AS-INDACENE BASED TRICYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME AS INHIBITORS OF IKK ENZYME ACTIVITY | BRISTOL MYERS SQUIBB CO (US) | 2010-04-21 | — | — | EP | disclosed |