Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 15/20 | 0.42 |
| ▸ | JAK3 | P52333 | 15/20 | 0.42 |
| ▸ | JAK1 | P23458 | 8/20 | 0.42 |
| ▸ | TYK2 | P29597 | 6/20 | 0.42 |
| ▸ | IKBKB | O14920 | 5/20 | 0.40 |
| ▸ | CHUK | O15111 | 4/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | NQO2 | P16083 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2768039 | 0.87 | IKBKB (0.43) | JAK2JAK3JAK1TYK2IKBKB | |
| SCHEMBL3040915 | 0.87 | JAK2 (0.42) | JAK2JAK3JAK1TYK2IKBKB | |
| SCHEMBL2768229 | 0.85 | IKBKB (0.46) | JAK2JAK3JAK1TYK2IKBKB | |
| SCHEMBL2767367 | 0.84 | IKBKB (0.47) | JAK2JAK3JAK1TYK2IKBKB | |
| SCHEMBL2767644 | 0.84 | IKBKB (0.42) | JAK2JAK3JAK1TYK2IKBKB | |
| SCHEMBL3046566 | 0.84 | IKBKB (0.46) | JAK2JAK3JAK1TYK2IKBKB | |
| SCHEMBL3545886 | 0.83 | IKBKB (0.46) | JAK2JAK3JAK1TYK2IKBKB | |
| SCHEMBL2768209 | 0.83 | JAK2 (0.48) | JAK2JAK3JAK1TYK2IKBKB | |
| SCHEMBL2768402 | 0.83 | IKBKB (0.39) | JAK2JAK3JAK1TYK2IKBKB | |
| SCHEMBL2769279 | 0.82 | IKBKB (0.45) | JAK2JAK3JAK1TYK2IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888584-B1 | 1, 6 -DIHYDRO- 1,3, 5, 6-TETRAAZA-AS-INDACENE BASED TRICYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME AS INHIBITORS OF IKK ENZYME ACTIVITY | BRISTOL MYERS SQUIBB CO (US) | 2010-04-21 | — | — | EP | disclosed |