SCHEMBL27686172

SCHEMBL27686172

NC(=O)c1c(CC(O)N2CCOCC2)c2ncc(Cc3ccc(F)cc3)cc2n(CC(=O)N2CCCC2)c1=O

nearest known ligand 0.40

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GRIN2B Q13224 18/20 0.40
GRIN1 Q05586 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27667098 0.99 GRIN2B (0.39) GRIN2BGRIN1
SCHEMBL27667135 0.97 GRIN2B (0.42) GRIN2B
SCHEMBL27667119 0.90 GRIN2B (0.44) GRIN2B
SCHEMBL27667064 0.89 GRIN2B (0.42) GRIN2BGRIN1
SCHEMBL27667097 0.89 GRIN2B (0.41) GRIN2BGRIN1
SCHEMBL27686095 0.86 GRIN2B (0.40) GRIN2BGRIN1
SCHEMBL27686178 0.86 PIK3CA (0.39) GRIN2B
SCHEMBL27667127 0.84 GRIN2B (0.40) GRIN2BGRIN1
SCHEMBL27666981 0.83 GRIN2B (0.47) GRIN2B
SCHEMBL27667082 0.82 GRIN2B (0.45) GRIN2BGRIN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1976915-A HIV integrase inhibitors SMITHKLINE BEECHAM CORP (US) 2007-06-06 CN disclosed