Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 5/20 | 0.36 |
| ▸ | CYSLTR1 | Q9Y271 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | SLC26A3 | P40879 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27686236 | 0.90 | GRM2 (0.38) | GRM2CYSLTR1MAPTCYP2C9CYP2C19 | |
| SCHEMBL27875302 | 0.85 | GRM2 (0.51) | GRM2CYSLTR1MAPTCYP2C9CYP2C19 | |
| SCHEMBL481219 | 0.85 | GRM2 (0.52) | GRM2CYSLTR1MAPTCYP2C9CYP2C19 | |
| SCHEMBL5199831 | 0.78 | MEN1 (0.38) | GRM2CYSLTR1MAPT | |
| SCHEMBL13108391 | 0.76 | CYSLTR1 (0.54) | GRM2CYSLTR1TDP1 | |
| SCHEMBL13108399 | 0.76 | CYSLTR1 (0.54) | GRM2CYSLTR1TDP1 | |
| SCHEMBL481199 | 0.76 | CYSLTR1 (0.54) | GRM2CYSLTR1TDP1 | |
| SCHEMBL27875299 | 0.75 | GRM2 (0.54) | GRM2CYSLTR1MAPTCYP2C9CYP2C19 | |
| SCHEMBL13108387 | 0.74 | GRM2 (0.44) | GRM2CYSLTR1MAPTCYP2C9CYP2C19 | |
| SCHEMBL13108393 | 0.74 | GRM2 (0.44) | GRM2CYSLTR1MAPTCYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101955470-B | Potentiators of glutamate receptors | LILLY CO ELI | 2012-06-13 | — | — | CN | disclosed |
| CN-101955470-A | Glutamate receptor potentiators | LILLY CO ELI | 2011-01-26 | — | — | CN | disclosed |
| CN-101061106-B | Glutamate receptor potentiators | LILLY CO ELI | 2010-09-29 | — | — | CN | disclosed |
| CN-101061106-A | Glutamate receptor potentiators | LILLY CO ELI (US) | 2007-10-24 | — | — | CN | disclosed |