Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 0.60 |
| ▸ | FBP1 | P09467 | 2/20 | 0.59 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.58 |
| ▸ | AURKA | O14965 | 2/20 | 0.58 |
| ▸ | KDR | P35968 | 2/20 | 0.58 |
| ▸ | INSR | P06213 | 1/20 | 0.58 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.58 |
| ▸ | FLT4 | P35916 | 1/20 | 0.58 |
| ▸ | CLK1 | P49759 | 1/20 | 0.58 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.58 |
| ▸ | TEK | Q02763 | 1/20 | 0.58 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.58 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.57 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.55 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27686218 | 0.89 | EGFR (0.60) | EGFRFBP1ERBB2AURKAKDR | |
| SCHEMBL6129182 | 0.87 | EGFR (0.75) | EGFRFBP1ERBB2AURKAKDR | |
| Water SCHEMBL28549001 | 0.86 | EGFR (0.74) | EGFRFBP1ERBB2AURKAKDR | |
| SCHEMBL2979125 | 0.85 | FBP1 (0.64) | EGFRFBP1ERBB2AURKAKDR | |
| SCHEMBL27667251 | 0.84 | EGFR (0.62) | EGFRFBP1ERBB2AURKAKDR | |
| SCHEMBL27686224 | 0.84 | EGFR (0.59) | EGFRFBP1ERBB2AURKAKDR | |
| SCHEMBL16212227 | 0.81 | FBP1 (0.59) | EGFRFBP1ERBB2AURKAKDR | |
| SCHEMBL27686240 | 0.80 | EGFR (0.63) | EGFRFBP1ERBB2AURKAKDR | |
| SCHEMBL27860183 | 0.79 | EGFR (0.63) | EGFRFBP1ERBB2AURKAKDR | |
| SCHEMBL17498549 | 0.79 | EGFR (0.78) | EGFRERBB2ERBB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1972688-A | 4-phenylamino-quinazolin-6-yl-amides | WARNER LAMBERT CO (US) | 2007-05-30 | — | — | CN | claimed |
| CN-1972688-B | 4-phenylamino-quinazolin-6-yl-amides | WARNER LAMBERT CO | 2012-06-27 | — | — | CN | disclosed |
| CN-1972688-A | 4-phenylamino-quinazolin-6-yl-amides | WARNER LAMBERT CO (US) | 2007-05-30 | — | — | CN | disclosed |