Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | ACACB | O00763 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14924082 | 1.00 | KDM4E (0.52) | KDM4EHTTPDE3BPDE3AALDH1A1 | |
| SCHEMBL23328644 | 0.81 | HTT (0.39) | HTTPDE3BPDE3AACACB | |
| SCHEMBL13695536 | 0.81 | KDM4E (0.55) | KDM4EHTTPDE3BPDE3AALDH1A1 | |
| SCHEMBL14924431 | 0.81 | KDM4E (0.55) | KDM4EHTTPDE3BPDE3AALDH1A1 | |
| SCHEMBL10034107 | 0.81 | KDM4E (0.55) | KDM4EHTTPDE3BPDE3AALDH1A1 | |
| SCHEMBL18436044 | 0.81 | KDM4E (0.55) | KDM4EHTTPDE3BPDE3AALDH1A1 | |
| SCHEMBL19194075 | 0.80 | KDM4E (0.48) | KDM4EHTTPDE3BPDE3AALDH1A1 | |
| SCHEMBL13370661 | 0.79 | HTT (0.54) | KDM4EHTTPDE3BPDE3AALDH1A1 | |
| SCHEMBL16671146 | 0.79 | HTT (0.54) | KDM4EHTTPDE3BPDE3AALDH1A1 | |
| SCHEMBL30748794 | 0.79 | HTT (0.54) | KDM4EHTTPDE3BPDE3AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8133513-B2 | Solid preparation having improved solubility | SHIONOGI & CO., LTD. (JP) | 2012-03-13 | — | — | US | disclosed |
| US-8133513-B2 | Solid preparation having improved solubility | SHIONOGI & CO., LTD. (JP) | 2012-03-13 | — | — | US | disclosed |
| US-20100240711-A1 | SOLID PREPARATION COMPRISING NPYY5 RECEPTOR ANTAGONIST | SHIONOGI & CO., LTD. (JP) | 2010-09-23 | — | — | US | disclosed |
| US-20090105312-A1 | SOLID PREPARATION HAVING IMPROVED SOLUBILITY | SHIONOGI & CO., LTD. (JP) | 2009-04-23 | — | — | US | disclosed |
| US-20090105312-A1 | SOLID PREPARATION HAVING IMPROVED SOLUBILITY | SHIONOGI & CO., LTD. (JP) | 2009-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105312-A1 | SOLID PREPARATION HAVING IMPROVED SOLUBILITY | NUDT1, PDE7A, SLC7A1 | KDM4E 3013/4885HTT 1214/4885PDE3B 745/4885 |
| US-20100240711-A1 | SOLID PREPARATION COMPRISING NPYY5 RECEPTOR ANTAGONIST | NPY5R, SSTR5, NPY1R | KDM4E 980/4885HTT 2630/4885PDE3B 1102/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.