SCHEMBL27691968

SCHEMBL27691968

O=C(O)/C=C/Cc1cccc(CO)c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EGFR P00533 1/20 0.46
ACMSD Q8TDX5 1/20 0.44
PRSS1 P07477 1/20 0.41
PRSS2 P07478 1/20 0.41
PRSS3 P35030 1/20 0.41
TSHR P16473 2/20 0.40
AKR1C3 P42330 4/20 0.40
AKR1C2 P52895 3/20 0.40
ENPP2 Q13822 1/20 0.39
MAOB P27338 1/20 0.39
HCAR2 Q8TDS4 4/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
ALDH1A1 P00352 3/20 0.39
LMNA P02545 1/20 0.39
CYP2D6 P10635 1/20 0.39
CYP2C19 P33261 1/20 0.39
KDM4E B2RXH2 1/20 0.38
PKM P14618 1/20 0.38
CNR2 P34972 1/20 0.38
FFAR1 O14842 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30345495 0.93 MAOB (0.44) MAOBHCAR2ALDH1A1LMNACYP2D6
SCHEMBL27802429 0.84 AKR1B1 (0.48) TSHRALDH1A1LMNACYP2C19KDM4E
SCHEMBL27802435 0.84 AKR1B1 (0.48) TSHRALDH1A1LMNACYP2C19KDM4E
Hydrochloric Acid SCHEMBL27864806 0.83 ENPP2 (0.43) TSHRENPP2HCAR2SMN1; SMN2ALDH1A1
SCHEMBL26695746 0.81 HCAR2 (0.59) EGFRHCAR2ALDH1A1FFAR1
SCHEMBL27549843 0.81 NPSR1 (0.53) MAOBHCAR2ALDH1A1LMNA
SCHEMBL29018928 0.81 AOC3 (0.51) ACMSDMAOB
SCHEMBL27556620 0.81 HCAR2 (0.59) EGFRHCAR2ALDH1A1FFAR1
SCHEMBL1233515 0.81 MAOB (0.61) MAOBHCAR2ALDH1A1LMNACYP2D6
SCHEMBL2555173 0.81 MAOB (0.61) MAOBHCAR2ALDH1A1LMNACYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102007098-B Therapeutic substituted cyclopentanes ALLERGAN INC 2014-05-07 CN disclosed
CN-101107225-B 12-aryl prostaglandin analogs ALLERGAN INC 2012-11-28 CN disclosed
CN-102007098-A Therapeutic substituted cyclopentanes ALLERGAN INC 2011-04-06 CN disclosed
CN-101107225-A 12-aryl prostaglandin analogs ALLERGAN INC (US) 2008-01-16 CN disclosed