Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 3/20 | 0.40 |
| ▸ | PPARD | Q03181 | 2/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.39 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.38 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | GCGR | P47871 | 1/20 | 0.38 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.38 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.38 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL485410 | 0.86 | CXCR2 (0.46) | KDM4EPPARAPPARDTRPV1EPHX2 | |
| SCHEMBL27713177 | 0.79 | CXCR2 (0.45) | KDM4EPPARAPPARDTRPV1EPHX2 | |
| SCHEMBL27693276 | 0.78 | KDM4E (0.41) | KDM4EPPARAPPARDPPARGTRPM8 | |
| SCHEMBL27713026 | 0.77 | KDM4E (0.73) | KDM4EERAP1CXCR2 | |
| SCHEMBL485514 | 0.76 | CXCR2 (0.57) | KDM4EPPARAPPARDPPARGERAP1 | |
| SCHEMBL485540 | 0.76 | CXCR2 (0.62) | KDM4EPPARAPPARDTRPV1EPHX2 | |
| SCHEMBL485436 | 0.75 | KDM4E (0.54) | KDM4ETRPV1EPHX2PPARGNR1H4 | |
| SCHEMBL3930532 | 0.74 | CXCR2 (0.53) | KDM4EPPARAPPARDPPARGERAP1 | |
| SCHEMBL485143 | 0.73 | CXCR2 (0.51) | KDM4EPPARAPPARDEPHX2PPARG | |
| SCHEMBL485691 | 0.73 | CXCR2 (0.44) | KDM4EPPARDERAP1CXCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101094830-A | Fused bicyclic carboxamide derivatives for use as CXCR2 inhibitors in the treatment of inflammation | SANOFI AVENTIS DEUTSCHLAND (DE) | 2007-12-26 | — | — | CN | claimed |