Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.39 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | PPARD | Q03181 | 2/20 | 0.39 |
| ▸ | PPARA | Q07869 | 2/20 | 0.39 |
| ▸ | PTPRC | P08575 | 1/20 | 0.39 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.39 |
| ▸ | PTPN9 | P43378 | 1/20 | 0.39 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.39 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.39 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL485338 | 0.85 | CXCR2 (0.49) | CXCR2KDM4EEPHX2NR1H4PPARD | |
| SCHEMBL27693225 | 0.79 | KDM4E (0.44) | CXCR2KDM4EEPHX2NR1H4CTNNB1 | |
| SCHEMBL485436 | 0.75 | KDM4E (0.54) | CXCR2KDM4EEPHX2NR1H4TRPV1 | |
| SCHEMBL485243 | 0.75 | CXCR2 (0.45) | CXCR2KDM4EEPHX2NR1H4PPARD | |
| SCHEMBL485456 | 0.74 | CXCR2 (0.49) | CXCR2KDM4E | |
| SCHEMBL484851 | 0.74 | CXCR2 (0.60) | CXCR2KDM4EEPHX2NR1H4PPARA | |
| SCHEMBL485751 | 0.74 | KDM4E (0.71) | CXCR2KDM4E | |
| SCHEMBL485484 | 0.73 | CXCR2 (0.49) | CXCR2KDM4E | |
| SCHEMBL485080 | 0.73 | CXCR2 (0.56) | CXCR2KDM4EPPARDPPARAPTPN1 | |
| SCHEMBL3925217 | 0.72 | CXCR2 (0.62) | CXCR2KDM4EPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101094830-A | Fused bicyclic carboxamide derivatives for use as CXCR2 inhibitors in the treatment of inflammation | SANOFI AVENTIS DEUTSCHLAND (DE) | 2007-12-26 | — | — | CN | claimed |