Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.35 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.34 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 3/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27712979 | 0.88 | CXCR2 (0.53) | CXCR2 | |
| SCHEMBL485695 | 0.86 | CXCR2 (0.56) | CXCR2ALDH1A1SMN1; SMN2NPSR1ALOX5AP | |
| SCHEMBL485478 | 0.85 | CXCR2 (0.56) | CXCR2ALDH1A1SMN1; SMN2NPSR1ALOX5AP | |
| Formic Acid SCHEMBL27693250 | 0.81 | MRGPRX4 (0.43) | HCRTR1HCRTR2POLBMAPT | |
| SCHEMBL485687 | 0.80 | MRGPRX4 (0.45) | ALOX5APHCRTR1HCRTR2POLBMAPT | |
| SCHEMBL485799 | 0.80 | MRGPRX4 (0.45) | HCRTR1HCRTR2POLBMAPT | |
| SCHEMBL27693416 | 0.79 | CXCR2 (0.38) | CXCR2ALDH1A1SMN1; SMN2NPSR1KDM4E | |
| SCHEMBL27693267 | 0.79 | CXCR2 (0.43) | CXCR2 | |
| SCHEMBL12467343 | 0.78 | CXCR2 (0.39) | CXCR2ALDH1A1RPS6KA3KDM4EHPGD | |
| SCHEMBL27693232 | 0.77 | CXCR2 (0.45) | CXCR2SLC6A9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101094830-A | Fused bicyclic carboxamide derivatives for use as CXCR2 inhibitors in the treatment of inflammation | SANOFI AVENTIS DEUTSCHLAND (DE) | 2007-12-26 | — | — | CN | claimed |
| CN-101094830-A | Fused bicyclic carboxamide derivatives for use as CXCR2 inhibitors in the treatment of inflammation | SANOFI AVENTIS DEUTSCHLAND (DE) | 2007-12-26 | — | — | CN | disclosed |