Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 5/20 | 0.45 |
| ▸ | SLC6A9 | P48067 | 4/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.37 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.37 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.33 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.33 |
| ▸ | STK39 | Q9UEW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27693240 | 0.92 | CXCR2 (0.44) | CXCR2SLC6A9P2RX1P2RX3P2RX4 | |
| SCHEMBL27693416 | 0.88 | CXCR2 (0.38) | CXCR2SLC6A9FFAR1MRGPRX4 | |
| SCHEMBL27693220 | 0.88 | CXCR2 (0.46) | CXCR2 | |
| SCHEMBL485485 | 0.87 | CXCR2 (0.60) | CXCR2SLC6A9FFAR1P2RX1P2RX3 | |
| SCHEMBL27713046 | 0.87 | CXCR2 (0.57) | CXCR2P2RX1P2RX3P2RX4P2RX7 | |
| SCHEMBL485136 | 0.85 | CXCR2 (0.58) | CXCR2SLC6A9FFAR1P2RX1P2RX3 | |
| Formic Acid SCHEMBL27693233 | 0.82 | CXCR2 (0.44) | CXCR2P2RX1P2RX3P2RX4P2RX7 | |
| SCHEMBL485567 | 0.81 | CXCR2 (0.47) | CXCR2P2RX1P2RX3P2RX4P2RX7 | |
| SCHEMBL485934 | 0.81 | CXCR2 (0.47) | CXCR2DRD4MRGPRX4 | |
| SCHEMBL27712958 | 0.80 | CXCR2 (0.57) | CXCR2RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101094830-A | Fused bicyclic carboxamide derivatives for use as CXCR2 inhibitors in the treatment of inflammation | SANOFI AVENTIS DEUTSCHLAND (DE) | 2007-12-26 | — | — | CN | claimed |
| CN-101094830-A | Fused bicyclic carboxamide derivatives for use as CXCR2 inhibitors in the treatment of inflammation | SANOFI AVENTIS DEUTSCHLAND (DE) | 2007-12-26 | — | — | CN | disclosed |