Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.39 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.37 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.37 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.37 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.37 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.36 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27713026 | 0.85 | KDM4E (0.73) | KDM4EERAP1CXCR2MCL1MEN1 | |
| SCHEMBL28766910 | 0.85 | KDM4E (0.52) | KDM4EERAP1CXCR2MCL1MEN1 | |
| SCHEMBL27693288 | 0.81 | CXCR2 (0.54) | KDM4ECXCR2MEN1KMT2ANPSR1 | |
| SCHEMBL27713024 | 0.79 | CXCR2 (0.52) | KDM4EERAP1CXCR2MEN1KMT2A | |
| SCHEMBL27693280 | 0.78 | KDM4E (0.43) | KDM4EERAP1CXCR2MEN1KMT2A | |
| SCHEMBL9657406 | 0.77 | BRD4 (0.47) | KDM4ECXCR2MCL1MEN1KMT2A | |
| SCHEMBL485029 | 0.77 | KDM4E (0.54) | KDM4EMCL1MEN1KMT2ANPSR1 | |
| SCHEMBL7586997 | 0.76 | KDM4E (0.52) | KDM4EMEN1KMT2ANPSR1ALDH1A1 | |
| SCHEMBL27693289 | 0.75 | CXCR2 (0.57) | ERAP1CXCR2MCL1BCL2L1THRB | |
| SCHEMBL484865 | 0.73 | KDM4E (0.44) | KDM4EERAP1CXCR2MCL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101094830-A | Fused bicyclic carboxamide derivatives for use as CXCR2 inhibitors in the treatment of inflammation | SANOFI AVENTIS DEUTSCHLAND (DE) | 2007-12-26 | — | — | CN | disclosed |