Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.52 |
| ▸ | LMNA | P02545 | 6/20 | 0.52 |
| ▸ | HPGD | P15428 | 6/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | MPO | P05164 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | NAAA | Q02083 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | ESRRG | P62508 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14036676 | 0.82 | NPSR1 (0.60) | KDM4ELMNAHPGDHSD17B10ALDH1A1 | |
| SCHEMBL28456818 | 0.80 | POLB (0.57) | HSD17B10ALDH1A1GAASMN1; SMN2NAAA | |
| SCHEMBL27693288 | 0.79 | CXCR2 (0.54) | KDM4ELMNAALDH1A1HTTKMT2A | |
| SCHEMBL7672296 | 0.78 | KDM4E (0.59) | KDM4ELMNAHPGDHSD17B10ALDH1A1 | |
| SCHEMBL7757842 | 0.78 | KDM4E (0.59) | KDM4ELMNAHPGDHSD17B10ALDH1A1 | |
| Bromide SCHEMBL6849900 | 0.76 | KDM4E (0.57) | KDM4ELMNAHPGDHSD17B10ALDH1A1 | |
| SCHEMBL27713026 | 0.76 | KDM4E (0.73) | KDM4ELMNAHPGDHSD17B10ALDH1A1 | |
| SCHEMBL28766910 | 0.76 | KDM4E (0.52) | KDM4EHPGDHSD17B10ALDH1A1TSHR | |
| SCHEMBL27693293 | 0.76 | KDM4E (0.52) | KDM4EHPGDHSD17B10ALDH1A1TSHR | |
| SCHEMBL28857264 | 0.75 | KDM4E (0.55) | KDM4ELMNAHPGDHSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1263725-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2002-12-11 | — | — | EP | disclosed |
| WO-2001062729-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2001-08-30 | — | — | WO | disclosed |