Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 5/20 | 0.36 |
| ▸ | CDC7 | O00311 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 4/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.33 |
| ▸ | CTSA | P10619 | 1/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27694236 | 0.89 | PDE4B (0.42) | TYMSPARP1JAK2GPR52 | |
| SCHEMBL27694237 | 0.88 | EDNRA (0.43) | PARP1CDC7PIK3CA | |
| SCHEMBL3183862 | 0.83 | TYMS (0.43) | TYMSPARP1JAK2PIK3CAEPHX1 | |
| SCHEMBL3269941 | 0.79 | TYMS (0.41) | TYMSCDC7PIK3CAEPHX1 | |
| SCHEMBL27694235 | 0.75 | KDR (0.37) | TYMSPARP1CDC7EPHX1 | |
| SCHEMBL28768818 | 0.73 | EDNRA (0.41) | PARP1CDC7JAK2 | |
| SCHEMBL27675818 | 0.72 | ICAM1 (0.39) | PARP1CDC7 | |
| SCHEMBL3188930 | 0.72 | TYMS (0.44) | TYMS | |
| SCHEMBL3167815 | 0.71 | TYMS (0.43) | TYMSPARP1 | |
| SCHEMBL27675749 | 0.71 | CDC7 (0.41) | PARP1CDC7JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100562521-C | Substituted thienopyrrole carboxylic acid amides, pyrrolothiazole carboxylic acid amides, and related analogs as inhibitors of casein kinase ie | AVENTIS PHARMA INC (US) | 2009-11-25 | — | — | CN | claimed |
| CN-101001861-A | Substituted thienopyrrole carboxylic acid amides, pyrrolothiazole carboxylic acid amides, and related analogs as inhibitors of casein kinase i epsilon | AVENTIS PHARMA INC (US) | 2007-07-18 | — | — | CN | claimed |
| CN-100562521-C | Substituted thienopyrrole carboxylic acid amides, pyrrolothiazole carboxylic acid amides, and related analogs as inhibitors of casein kinase ie | AVENTIS PHARMA INC (US) | 2009-11-25 | — | — | CN | disclosed |
| CN-101001861-A | Substituted thienopyrrole carboxylic acid amides, pyrrolothiazole carboxylic acid amides, and related analogs as inhibitors of casein kinase i epsilon | AVENTIS PHARMA INC (US) | 2007-07-18 | — | — | CN | disclosed |