Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC1 | P48995 | 1/20 | 0.40 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.40 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.40 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.40 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27717168 | 0.92 | MAPK1 (0.42) | TRPC1TRPC3STIM1ORAI1CYP2C9 | |
| SCHEMBL2096523 | 0.90 | NPC1 (0.50) | TRPC1TRPC3STIM1ORAI1GPR27 | |
| SCHEMBL27717256 | 0.88 | MEN1 (0.47) | TRPC1TRPC3STIM1ORAI1NPC1 | |
| SCHEMBL27717099 | 0.88 | MEN1 (0.53) | MAPK1NPC1MAPTRAB9AMEN1 | |
| SCHEMBL2094733 | 0.85 | PTGS1 (0.41) | CYP2C9MAPK1MAPTAURKAKDR | |
| SCHEMBL2093588 | 0.84 | LMNA (0.43) | TRPC1TRPC3STIM1ORAI1CYP2C9 | |
| SCHEMBL2091612 | 0.84 | STIM1 (0.55) | TRPC1TRPC3STIM1ORAI1CYP2C9 | |
| SCHEMBL10187707 | 0.83 | MEN1 (0.44) | MAPK1NPC1MAPTRAB9AAURKA | |
| SCHEMBL2095257 | 0.83 | CRACR2A (0.41) | TRPC1TRPC3STIM1ORAI1NPC1 | |
| SCHEMBL2094439 | 0.82 | KDM4E (0.40) | CYP2C9MAPK1MAPTAURKAKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101083985-A | Compounds for inflammation and immune-related uses | SYNTA PHARMACEUTICALS CORP (US) | 2007-12-05 | — | — | CN | claimed |
| CN-101083985-A | Compounds for inflammation and immune-related uses | SYNTA PHARMACEUTICALS CORP (US) | 2007-12-05 | — | — | CN | disclosed |