Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 2/20 | 0.52 |
| ▸ | BTK | Q06187 | 2/20 | 0.52 |
| ▸ | AURKA | O14965 | 2/20 | 0.52 |
| ▸ | RET | P07949 | 2/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.52 |
| ▸ | LTK | P29376 | 2/20 | 0.52 |
| ▸ | KDR | P35968 | 2/20 | 0.52 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.52 |
| ▸ | FLT3 | P36888 | 2/20 | 0.52 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.52 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.52 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.52 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.52 |
| ▸ | CAMK1D | Q8IU85 | 2/20 | 0.52 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.52 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.52 |
| ▸ | PLK4 | O00444 | 1/20 | 0.52 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27698209 | 0.80 | IKBKB (0.61) | CHEK1BTKAURKARETFGFR1 | |
| SCHEMBL27709861 | 0.79 | IKBKB (0.64) | CHEK1BTKCDC7CHEK2PTPN1 | |
| SCHEMBL27698212 | 0.78 | CHEK1 (0.50) | CHEK1BTKAURKARETFGFR1 | |
| SCHEMBL1421939 | 0.71 | BTK (0.58) | CHEK1BTKAURKARETFGFR1 | |
| SCHEMBL13606474 | 0.71 | CDK5 (0.48) | CHEK1BTKCDK5CLK4ROCK1 | |
| SCHEMBL23185496 | 0.70 | BTK (0.57) | CHEK1BTKAURKARETFGFR1 | |
| SCHEMBL16258828 | 0.70 | BTK (0.57) | CHEK1BTKAURKARETFGFR1 | |
| SCHEMBL20487617 | 0.70 | BTK (0.57) | CHEK1BTKAURKARETFGFR1 | |
| SCHEMBL29232675 | 0.70 | BTK (0.57) | CHEK1BTKAURKARETFGFR1 | |
| SCHEMBL28494095 | 0.70 | ADORA2A (0.50) | CHEK1BTKAURKARETFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101005836-A | Novel indazole carboxamides and their use | SMITHKLINE BEECHAM CORP (US) | 2007-07-25 | — | — | CN | disclosed |