Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 4/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2187979 | 0.92 | MEN1 (0.55) | LMNAHTTMAPTNPSR1KMT2A | |
| SCHEMBL2213153 | 0.90 | LMNA (0.49) | LMNAHTTMAPTNPSR1KMT2A | |
| SCHEMBL2187717 | 0.87 | LMNA (0.53) | LMNAHTTMAPTNPSR1KMT2A | |
| SCHEMBL2186962 | 0.86 | LMNA (0.56) | LMNAHTTMAPTNPSR1KMT2A | |
| SCHEMBL2187480 | 0.86 | LMNA (0.48) | LMNAHTTMAPTNPSR1KMT2A | |
| SCHEMBL2187384 | 0.85 | MEN1 (0.47) | LMNAHTTMAPTNPSR1KMT2A | |
| SCHEMBL2185430 | 0.85 | LMNA (0.50) | LMNAHTTMAPTNPSR1KMT2A | |
| SCHEMBL2213291 | 0.85 | MAPT (0.52) | LMNAHTTMAPTNPSR1KMT2A | |
| SCHEMBL2185672 | 0.84 | LMNA (0.53) | LMNAHTTMAPTNPSR1KMT2A | |
| SCHEMBL2186478 | 0.83 | KMT2A (0.48) | LMNAHTTMAPTNPSR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101031567-B | Novel heterocyclic NF-kB inhibitors | 4SC Corp.,Ltd. (DE) | 2011-12-21 | — | — | CN | disclosed |
| CN-101031567-A | Novel heterocyclic NF-kB inhibitors | 4SC AG (DE) | 2007-09-05 | — | — | CN | disclosed |