Citric Acid

Citric Acid

SCHEMBL276989

O=C(O)CC(O)(CC(=O)O)C(=O)O.[Fe].[NaH]

nearest known ligand 0.88

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2

The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MEN1 known ✓ O00255 1/20 0.40
ALDH1A1 P00352 2/20 0.88
HMGCR P04035 1/20 0.46
CHRM1 P11229 1/20 0.46
TBXA2R P21731 1/20 0.46
ADRA1A P35348 1/20 0.46
TSHR P16473 2/20 0.43
CYP2D6 P10635 2/20 0.43
CYP2C19 P33261 1/20 0.43
HIF1A Q16665 1/20 0.43
ACLY P53396 4/20 0.42
KDM4E B2RXH2 2/20 0.42
LMNA P02545 2/20 0.42
MAPT P10636 1/20 0.42
ALOX15 P16050 1/20 0.42
SLC13A5 Q86YT5 4/20 0.41
CPT2 P23786 1/20 0.41
CYP1A2 P05177 1/20 0.40
KMT2A Q03164 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Citric Acid SCHEMBL4832768 1.00 ALDH1A1 (0.88) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL27684023 1.00 ALDH1A1 (0.88) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL27623018 1.00 ALDH1A1 (0.88) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL26630598 0.97 ALDH1A1 (0.83) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL28117275 0.97 ALDH1A1 (0.83) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL28175509 0.97 ALDH1A1 (0.83) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL28175508 0.97 ALDH1A1 (0.83) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL28425653 0.97 ALDH1A1 (0.83) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL11857836 0.97 ALDH1A1 (0.94) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL4819877 0.97 ALDH1A1 (0.94) ALDH1A1HMGCRCHRM1TBXA2RADRA1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 535 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119662625-A Conjugated microporous polymer-chlorella complex, preparation method thereof and application thereof in treatment of organic pollutants in sewage 中国科学院生态环境研究中心 2025-03-21 CN claimed
EP-3192506-B1 PROPHYLACTIC/AMELIORATING AGENT FOR ADULT DISEASES COMPRISING 5-AMINOLEVULINIC ACID, DERIVATIVE OF 5-AMINOLEVULINIC ACID, OR SALT OF 5-AMINOLEVULINIC ACID OR THE DERIVATIVE OR 5-AMINOLEVULINIC ACID AS ACTIVE INGREDIENT SBI PHARMACEUTICALS CO LTD (JP) 2024-12-11 EP claimed
EP-4470997-A1 IRON SUPPLY AGENT FOR PLANT GROWTH Sobue Clay Co., Ltd. (JP) 2024-12-04 EP claimed
WO-2024214128-A1 IRON SUPPLY AGENT FOR PLANT GROWTH ソブエクレー株式会社 2024-10-17 WO claimed
WO-2024189758-A1 IRON PREPARATION FOR RAISING ANIMALS/PLANTS AND METHOD FOR PRODUCING SAME, AND IRON SUPPLY AGENT FOR RAISING ANIMALS/PLANTS ソブエクレー株式会社 2024-09-19 WO claimed
US-20240173283-A1 PROPHYLACTIC AGENT OR THERAPEUTIC AGENT FOR SIDE EFFECTS OF ANTHRACYCLINE ANTICANCER AGENT SBI PHARMACEUTICALS CO., LTD. (JP) 2024-05-30 US claimed
EP-3508200-B1 AQUEOUS FORMULATION CONTAINING 5-AMINOLEVULINIC ACID OR THE LIKE SBI PHARMACEUTICALS CO LTD (JP) 2024-04-10 EP claimed
EP-4316480-A1 PROPHYLACTIC AGENT OR THERAPEUTIC AGENT FOR SIDE EFFECTS OF ANTHRACYCLINE ANTICANCER AGENT Kyushu University, National University Corporation (JP) 2024-02-07 EP claimed
CN-116997335-A Preventive or therapeutic agent for side effects of anthracycline anticancer agent 国立大学法人九州大学 2023-11-03 CN claimed
WO-2022202477-A1 PROPHYLACTIC AGENT OR THERAPEUTIC AGENT FOR SIDE EFFECTS OF ANTHRACYCLINE ANTICANCER AGENT 国立大学法人九州大学 2022-09-29 WO claimed
WO-2006068697-A2 COMPOSITIONS INCLUDING IRON DRUGTECH CORPORATION (US) 2006-06-29 WO claimed
WO-2006068729-A2 METHODS AND COMPOSITIONS FOR ENHANCING IRON ABSORPTION DRUGTECH CORPORATION (US) 2006-06-29 WO claimed
US-20060134227-A1 Compositions including iron DRUGTECH CORPORATION 2006-06-22 US claimed
WO-2003086321-A2 MODIFIED RELEASE MINERALS DRUGTECH CORPORATION (US) 2003-10-23 WO claimed
US-20030190355-A1 Modified release minerals DRUGTECH CORPORATION 2003-10-09 US claimed
US-5520725-A Dental glass ionomer cement composition GC CORPORATION (JP) 1996-05-28 US claimed
EP-0401377-B1 IRON-CONTAINING PREPARATION FOR USE AS NMR CONTRAST MEDIUM OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1993-09-15 EP claimed
US-5174987-A Administering orally the contrast media consists of sodium carbonate or bicarbonate, ferrous or ferric compounds, and a neutralizing agent; easy to drink; clear and accurate contrast imaging of inner organs OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1992-12-29 US claimed
EP-0401377-A1 IRON-CONTAINING PREPARATION FOR USE AS NMR CONTRAST MEDIUM OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1990-12-12 EP claimed
US-4173453-A Topical hair coloring formulation in the form of suspension, lotion and cream CDC Research Inc. (US) 1979-11-06 US claimed