Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 14/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 13/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 9/20 | 0.50 |
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | GLA | P06280 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | USP2 | O75604 | 2/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4479249 | 0.83 | KDM4E (0.62) | KDM4EALDH1A1HSD17B10MAPTPKM | |
| SCHEMBL27699295 | 0.80 | KDM4E (0.46) | KDM4EALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL8269691 | 0.77 | KDM4E (0.52) | KDM4EALDH1A1HSD17B10MAPTPKM | |
| SCHEMBL4483851 | 0.75 | KDM4E (0.49) | KDM4EALDH1A1HSD17B10MAPTPKM | |
| SCHEMBL8269666 | 0.74 | KDM4E (0.46) | KDM4EALDH1A1HSD17B10MAPTMEN1 | |
| SCHEMBL4468097 | 0.74 | KDM4E (0.47) | KDM4EALDH1A1HSD17B10MAPTPKM | |
| SCHEMBL8269684 | 0.72 | ALDH1A1 (0.43) | KDM4EALDH1A1HSD17B10MAPTMEN1 | |
| SCHEMBL27699452 | 0.70 | KDM4E (0.70) | KDM4EALDH1A1HSD17B10MAPTMEN1 | |
| SCHEMBL10921484 | 0.69 | ALDH1A1 (0.53) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL14008627 | 0.68 | ALDH1A1 (0.46) | KDM4EALDH1A1HSD17B10MAPTPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101146769-A | Azolylacylguanidines as beta-secretase inhibitors | WYETH CORP (US) | 2008-03-19 | — | — | CN | disclosed |