Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pidolic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAD | P27708 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | BLM | P54132 | 2/20 | 0.34 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.34 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.34 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
| ▸ | IKBKB | O14920 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pidolic Acid SCHEMBL7554345 | 0.92 | CAD (0.46) | CADMEN1KMT2ASMN1; SMN2POLB | |
| Pidolic Acid SCHEMBL223918 | 0.92 | — | — | |
| Pidolic Acid SCHEMBL15790 | 0.92 | — | — | |
| Pidolic Acid SCHEMBL15791 | 0.92 | — | — | |
| Pidolic Acid SCHEMBL10937920 | 0.92 | CAD (0.46) | CADMEN1KMT2ASMN1; SMN2POLB | |
| Pidolic Acid SCHEMBL29479230 | 0.92 | — | — | |
| Pidolic Acid SCHEMBL152441 | 0.92 | CAD (0.46) | CADMEN1KMT2ASMN1; SMN2POLB | |
| Pidolic Acid SCHEMBL1239532 | 0.92 | CAD (0.46) | CADMEN1KMT2ASMN1; SMN2POLB | |
| Pidolic Acid SCHEMBL28073235 | 0.90 | CAD (0.40) | CADMEN1KMT2ASMN1; SMN2POLB | |
| Pidolic Acid SCHEMBL28952725 | 0.90 | CAD (0.40) | CADMEN1KMT2ASMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101166539-B | Compositions and methods involving MDA-7 for the treatment of cancer | UNIV TEXAS | 2012-01-04 | — | — | CN | disclosed |
| CN-101166539-A | Compositions and methods involving MDA-7 for the treatment of cancer | UNIV TEXAS (US) | 2008-04-23 | — | — | CN | disclosed |