Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.77 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.58 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.54 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.54 |
| ▸ | HTR3B | O95264 | 2/20 | 0.54 |
| ▸ | HTR3A | P46098 | 2/20 | 0.54 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.54 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23086436 | 1.00 | POLB (0.77) | POLBPTPN2PTPN1SMN1; SMN2CYP2C19 | |
| SCHEMBL23086434 | 1.00 | POLB (0.77) | POLBPTPN2PTPN1SMN1; SMN2CYP2C19 | |
| SCHEMBL23086437 | 1.00 | POLB (0.77) | POLBPTPN2PTPN1SMN1; SMN2CYP2C19 | |
| SCHEMBL27228999 | 0.89 | POLB (0.65) | POLBPTPN2PTPN1SMN1; SMN2CYP2C19 | |
| SCHEMBL27232172 | 0.89 | POLB (0.65) | POLBPTPN2PTPN1SMN1; SMN2CYP2C19 | |
| SCHEMBL743845 | 0.87 | POLB (1.00) | POLBPTPN2PTPN1SMN1; SMN2CYP2C19 | |
| SCHEMBL2454638 | 0.83 | POLB (0.71) | POLBPTPN2PTPN1SMN1; SMN2CYP2C19 | |
| SCHEMBL31050717 | 0.83 | POLB (0.71) | POLBPTPN2PTPN1SMN1; SMN2CYP2C19 | |
| SCHEMBL2454639 | 0.83 | POLB (0.71) | POLBPTPN2PTPN1SMN1; SMN2CYP2C19 | |
| SCHEMBL4755217 | 0.82 | CHRNA7 (0.73) | CYP2C19CHRNA7HTR3EHTR3BHTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1960383-B1 | 5-SUBSTITUTED INDOLE-2-CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2010-04-28 | — | — | EP | disclosed |