Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 1.00 |
| ▸ | HTR3E | A5X5Y0 | 3/20 | 0.68 |
| ▸ | HTR3B | O95264 | 3/20 | 0.68 |
| ▸ | HTR3A | P46098 | 3/20 | 0.68 |
| ▸ | HTR3D | Q70Z44 | 3/20 | 0.68 |
| ▸ | HTR3C | Q8WXA8 | 3/20 | 0.68 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.68 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.60 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | GMNN | O75496 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3977630 | 0.95 | POLB (0.90) | POLBHTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL3977633 | 0.95 | POLB (0.90) | POLBHTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL23086436 | 0.87 | POLB (0.77) | POLBHTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL23086434 | 0.87 | POLB (0.77) | POLBHTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL23086437 | 0.87 | POLB (0.77) | POLBHTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL2770045 | 0.87 | POLB (0.77) | POLBHTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL636578 | 0.84 | POLB (0.72) | POLBCYP2D6CYP2C19LMNAPTPN2 | |
| SCHEMBL16457010 | 0.84 | POLB (0.72) | POLBCYP2D6CYP2C19LMNAPTPN2 | |
| SCHEMBL636577 | 0.84 | POLB (0.72) | POLBCYP2D6CYP2C19LMNAPTPN2 | |
| SCHEMBL636579 | 0.84 | POLB (0.72) | POLBCYP2D6CYP2C19LMNAPTPN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8853241-B2 | Biaryl substituted azabicyclic alkane derivatives | ABBVIE INC. (US) | 2014-10-07 | — | — | US | disclosed |
| EP-2431368-B1 | CNS active fused bicycloheterocycle substituted azabicyclic alkane derivatives | ABBVIE BAHAMAS LTD (BS) | 2014-08-27 | — | — | EP | disclosed |
| EP-2280010-B1 | Biaryl substituted azabicyclic alkane derivatives as nicotinic acetylcholine receptor activity modulators | ABBOTT LAB (US) | 2012-12-19 | — | — | EP | disclosed |
| EP-2431368-A1 | CNS active fused bicycloheterocycle substituted azabicyclic alkane derivatives | Abbott Laboratories (US) | 2012-03-21 | — | — | EP | disclosed |
| EP-2018380-B1 | Cns active fused bicycloheterocycle substituted azabicyclic alkane derivatives | ABBOTT LAB (US) | 2011-10-19 | — | — | EP | disclosed |
| US-20110124676-A1 | BIARYL SUBSTITUTED AZABICYCLIC ALKANE DERIVATIVES | ABBOTT LABORATORIES (US) | 2011-05-26 | — | — | US | disclosed |
| US-7902222-B2 | Biaryl substituted azabicyclic alkane derivatives | ABBOTT LABORATORIES (US) | 2011-03-08 | — | — | US | disclosed |
| EP-2280010-A2 | Biaryl substituted azabicyclic alkane derivatives as nicotinic acetylcholine receptor activity modulators | Abbott Laboratories (US) | 2011-02-02 | — | — | EP | disclosed |
| US-7872017-B2 | Fused bicycloheterocycle substituted azabicyclic alkane derivatives | ABBOTT LABORATORIES (US) | 2011-01-18 | — | — | US | disclosed |
| US-20100305089-A1 | Fused Bicycloheterocycle Substituted Azabicyclic Alkane Derivatives | ABBOTT LABORATORIES (US) | 2010-12-02 | — | — | US | disclosed |
| US-20090192186-A1 | BIARYL SUBSTITUTED AZABICYCLIC ALKANE DERIVATIVES | ABBOTT LABORATORIES (US) | 2009-07-30 | — | — | US | disclosed |
| US-20080045539-A1 | FUSED BICYCLOHETEROCYCLE SUBSTITUTED AZABICYCLIC ALKANE DERIVATIVES | ABBVIE INC. | 2008-02-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090192186-A1 | BIARYL SUBSTITUTED AZABICYCLIC ALKANE DERIVATIVES | MALT1, AADAC, ALK | POLB 853/4885HTR3E 2400/4885HTR3B 2191/4885 |
| US-20080045539-A1 | FUSED BICYCLOHETEROCYCLE SUBSTITUTED AZABICYCLIC ALKANE DERIVATIVES | MALT1, BMP2, ALKBH2 | POLB 727/4885HTR3E 2605/4885HTR3B 2524/4885 |
| US-20110124676-A1 | BIARYL SUBSTITUTED AZABICYCLIC ALKANE DERIVATIVES | MALT1, AADAC, ALK | POLB 853/4885HTR3E 2400/4885HTR3B 2191/4885 |
| US-20100305089-A1 | Fused Bicycloheterocycle Substituted Azabicyclic Alkane Derivatives | MALT1, BMP2, ALKBH2 | POLB 727/4885HTR3E 2605/4885HTR3B 2524/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.